DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhe and bche

DIOPT Version :9

Sequence 1:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	161/533 - (30%)
Similarity:	248/533 - (46%)	Gaps:	68/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TVDQLTVCPPSVGCLKGTNL--------QGYQSERFE----AFMGIPYALPPIGDLRFSNPKVMP 80
            |:....||...|.|...|::        .|.|...|.    ||:|||||.||||||||..|....
Frog    13 TICFTVVCICCVNCNGETDIVDTKYGKVTGVQISVFSGIITAFLGIPYAEPPIGDLRFKKPVPHK 77

  Fly    81 KLLGMYDASAPKMDCIQK-NYLLP--------TPVVYGDEDCLYLNVYRPEIRKSALPVMVYIHG 136
            ....:::||.....|.|. :.:.|        .|.....|||||||::.|..:.....|||:|:|
Frog    78 PWSEIWNASQYGNSCYQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPTPKPRNASVMVWIYG 142

  Fly   137 GGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS---TQDAVMSGNFGLKDQNLALRWV 198
            |.|..|::...:...::...:..||:|:|.||||..|||:   ..:|  .||.||.||.|||:||
Frog   143 GSFETGTSSLDLYDGKFLARTERVIVVSMNYRLGALGFLAFPGNNEA--PGNVGLFDQRLALQWV 205

  Fly   199 QRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARL 263
            ..||..|||:|:.:||||:||||.:...|:|||:|||.|.|.|..|.|||.|:|:..:.....|.
Frog   206 YENIAAFGGNPKSITIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRA 270

  Fly   264 LAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMT----NFRPVVEEGLEVDAF 324
            |. .|::.:....:..::...||..:..::......:    :.|.:    ||.|.|:     ..|
Frog   271 LT-LANLLNCFYRNETEIIACLRNKSPEEIFEKAVSV----LPHRSVIEVNFPPTVD-----GDF 325

  Fly   325 LNAHPMDMLAQG-MPTSIPLLLGTVPGEGAVRVV-NILGNETLRQSFNLRFDELLQELLEFPASF 387
            |...|..::..| :.....:|.|....||:..:| .:.|.....:||..|........|.||.:
Frog   326 LIEMPEILMQLGQLKKKTQILTGVNKDEGSYFLVYGLPGFSKDHESFINRTQFHKSVKLAFPKA- 389

  Fly   388 SQDRREKMMDLLVEVYFQGQHEVNELTVQGFM-NLISDRGFKQPLYNTIHKNVCHTPNPVYLYSF 451
                .|..:|.::..|...:.|.|....:..| :::.|..|..||......| ....|..|||.|
Frog   390 ----TELAIDSVLFHYTNWEDEQNPSHNRDAMDDIVGDYNFICPLLEFTKWN-SELGNNAYLYYF 449

  Fly   452 NYQGPLSYASAYTSANVT--GKYGVVHCDDLLYLFRSPLLFPDFQR-NSTEAK--VIHSFVDYFV 511
            :::          |:.:|  |..||:|..::.::|..|:    ::| |.|:|:  :..:.:.|:.
Frog   450 HHR----------SSKLTWPGWMGVMHGYEIEFVFGIPM----YRRLNYTKAEETLSRTLMRYWA 500

  Fly   512 HFAKFGKPRNSES 524
            :|||.|.|..::|
Frog   501 NFAKTGNPNGAQS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	157/521 (30%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	155/514 (30%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010