Protein Alignment Jhe and nlgn3

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_012823589.1
• Gene: nlgn3 / 100329188
• XenbaseID: XB-GENE-977261
• Length: 843
• Species: Xenopus tropicalis
• Alignment Length: 623
• Identity: 170/623 - (27%)
• Similarity: 264/623 - (42%)
• Gaps: 129/623 - (20%)

  Fly    40 GCLKGTNLQGYQSE---RFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQK--- 98
            |.|:||.:. ..||   ..:.::|:|||.||:|:.||..|:..|...|:.:|:.....|.|.
 Frog    43 GKLRGTRVP-LPSEILGPVDQYLGVPYAAPPVGEKRFLPPEPPPSWSGIRNATHFSPVCPQNIQN 106

  Fly    99 ---NYLLPT------PVVYG-----DEDCLYLNVYRPE----------IRK-------------- 125
               :.::|.      ..|.|     .|||||||:|.|.          :||
 Frog   107 AVPDIMMPVWFTSNLDTVTGYLQEQSEDCLYLNIYVPTEDVKRISKECVRKPNKKICRKGGPSAK 171

  Fly   126 --------------------SALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLG 170
                                .|.|||||||||.:..|| |..:.| ......|.|:::|:.||:|
 Frog   172 KQGEELSDNDEDEEGDIRDTGAKPVMVYIHGGSYMEGS-GNMIDG-SVLASYGNVVVITLNYRVG 234

  Fly   171 PFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHG 235
            ..|||||.|....||:||.||..|||||..|:.||||||.|:|:||...|.....:..||..|.|
 Frog   235 VLGFLSTGDQAAKGNYGLLDQIQALRWVSENVAFFGGDPHRITVFGSGIGASCVSLLTLSHHSEG 299

  Fly   236 LFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGL 300
            ||.|.|..||:|...:|:..||::..|||||..   ....|.||.:...||:.:|.:|:..
 Frog   300 LFQRAIIQSGSALSSWAVNYQPVKYTRLLAEKV---GCNVLDTVDMVDCLRQKSAKELVEQ---- 357

  Fly   301 KYWDVD----HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILG 361
               |:.    |:. |.||::..:..|     .|..::.||...:..::||...|||...|.|::.
 Frog   358 ---DIQPARYHVA-FGPVIDGDVIPD-----DPEILMEQGEFLNYDIMLGVNQGEGLKFVENVVD 413

  Fly   362 NE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLIS 423
            .|  .....|:......:..|..:|     :.::.:.:.:..:|.......| |...:..:.|.:
 Frog   414 AEDGVSGSDFDYSVSNFVDNLYGYP-----EGKDTLRETIKFMYTDWADRDNPETRRKTLVALFT 473

  Fly   424 DRGFKQPLYNT--IHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRS 486
            |..:.:|...|  :|   ....:|.|.|:|.:........|:..|        .|.|::.|:|..
 Frog   474 DHQWVEPSVVTADLH---ARYGSPTYFYAFYHHCQSLMKPAWADA--------AHGDEVPYVFGV 527

  Fly   487 PL-----LFP-DFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHE 545
            |:     ||| :|.:|......:  .:.|:.:|||.|.|...   .|...:.:.::.:   .:.|
 Frog   528 PMVGPTDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNKP---VPQDTKFIHTKAN---RFEE 584

  Fly   546 FA----NAPD---AYQGFEVHVASEFQTDRVNLWSHIL 576
            .|    |..|   .:.|.:..|...::..:|..|.|::
 Frog   585 VAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	160/565 (28%)
nlgn3	XP_012823589.1	COesterase	35..618	CDD:395084	168/617 (27%)