DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ache

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	150/520 - (28%)
Similarity:	235/520 - (45%)	Gaps:	87/520 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTLM--PGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFA 90
            |.:||..:  ||   |...||:|||||:||||..|...|.|..||.|:|||...::.|.|  |..
  Rat    46 GQLRGIRLKAPG---GPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQ--YVD 105

  Fly    91 KEW-GLMGV----------EDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLM 144
            ..: |..|.          ||||||||:.|..|.....||:::|:||||:||::........:|.
  Rat   106 TLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLA 170

  Fly   145 DTNKVVMVTMNYRLGPFGFLS-TGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSA 208
            .....|:|:||||:|.||||: .|....|||.|..||||||||:|::||.|||||..||:.|.||
  Rat   171 QVEGTVLVSMNYRVGTFGFLALPGSRDAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESA 235

  Fly   209 GGISAHLHMISPNSKGLFQNSMSLTGT-----MFLSAMKILKDPLSQARRLG----------KEL 258
            |..|..:|::|..|:.||..::..:||     ..:||.:..:.....||.:|          .||
  Rat   236 GAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL 300

  Fly   259 AIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHR 323
             |....:..:|||.:...:|.|:            :::...:.:||::..    ||.:.|.....
  Rat   301 -ISCLRTRPAQDLVDHEWHVLPQ------------ESIFRFSFVPVVDGD----FLSDTPEALIN 348

  Fly   324 AGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALL----LNLPEGTPVQMVS 384
            .|....:..::.:..  .|||.|::...  |....: ||:.:.....|    :.:|:.:.:...:
  Rat   349 TGDFQDLQVLVGVVK--DEGSYFLVYGV--PGFSKD-NESLISRAQFLAGVRIGVPQASDLAAEA 408

  Fly   385 EILDAYDF---KGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGL 446
            .:|...|:   :..:...|.|   :.:.||.|...|:.:.......    :...::.||||....
  Rat   409 VVLHYTDWLHPEDPAHLRDAM---SAVVGDHNVVCPVAQLAGRLAA----QGARVYAYIFEHRAS 466

  Fly   447 NSITKFFAGTTDDYGLGAVH---MDDGL-HTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG 507
            ......:.|....|.:..:.   :|..| :|:             |:....||:....|:||:||
  Rat   467 TLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTV-------------EERIFAQRLMKYWTNFARTG 518

Fly 508 507
Rat 519 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	149/517 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/104 (48%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	150/520 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910