Protein Alignment Jhedup and TG

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 143/570 - (25%)
• Similarity: 226/570 - (39%)
• Gaps: 131/570 - (22%)

  Fly    42 EFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV-EDCLYLN 105
            :.:.|:|:|:|.||:...|.:.|.|.. |.|..||...:.||.|..  .:.....|| |||||||
Human  2224 QVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQPG--TRTSTSPGVSEDCLYLN 2285

  Fly   106 VYRPKNRAEDKLPVMVYIH---------GGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPF 161
            |:.|:|.|.: ..|:|:.|         |.....||         :|.....:::||.:||:|.|
Human  2286 VFIPQNVAPN-ASVLVFFHNTMDREESEGWPAIDGS---------FLAAVGNLIVVTASYRVGVF 2340

  Fly   162 GFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMI---SPNSK 223
            ||||:|...:.||:|..||..||.|:|.||..|||||::|::.....|...|.:|::   :.||:
Human  2341 GFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQ 2405

  Fly   224 GLFQNSMSLTGTMFLSAMKILKD-PLSQARRLGKELAIDQAESLSSQDLAEALR-------NVCP 280
             ||:.::.:.|:....|..|..: ...||..|.||::...:   |||::...||       |...
Human  2406 -LFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMS---SSQEVVSCLRQKPANVLNDAQ 2466

  Fly   281 KKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWI---LSLSSRAGE 342
            .|||........|.        ||::.    .||.|.|     |..:.:..|:   |.:.|...:
Human  2467 TKLLAVSGPFHYWG--------PVIDG----HFLREPP-----ARALKRSLWVEVDLLIGSSQDD 2514

  Fly   343 GSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAE 407
            |       .||   ||:..:.|.|...            ..|.....|....:||..:.  ..|.
Human  2515 G-------LIN---RAKAVKQFEESRG------------RTSSKTAFYQALQNSLGGED--SDAR 2555

  Fly   408 ISGDFNFYYPIYETISSYVTYANLEEN---------PLFIYIFEFAGLNSITKFFAGTTDDYGLG 463
            :.....:||.:..:...|.:::...||         |:......:|.......|.....::||.|
Human  2556 VEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHG 2620

  Fly   464 AVHMDDGLHTIRIPVSFDDFP---------KDSEDAKVIQRMSSLMTDFAKTG--VFHEESICKV 517
            ::.:   |..::..:....:|         :.|...|::|..|    .|.::|  .:..|...||
Human  2621 SLEL---LADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFS----HFIRSGNPNYPYEFSRKV 2678

  Fly   518 SDF--------KEQGMCNYLHFG-------GNKE-------KYLEDIRNS 545
            ..|        ...|..||..|.       |.|:       ||:..::.|
Human  2679 PTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSKYISSLKTS 2728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	130/509 (26%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		143/570 (25%)
		COesterase	2197..2718	CDD:395084	140/558 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768		1/2 (50%)