DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces2j

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	166/521 - (31%)
Similarity:	256/521 - (49%)	Gaps:	71/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYF- 89
            |.:||:.  :...:|| ...|:|||||:|||||||...|...|||.||.||.:....|:|.:..
  Rat    59 GQVRGSFVHVKDTKSG-IHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTAMMN 122

  Fly    90 ---AKEWGLMGV---EDCLYLNVYRPKNRAED-KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTN 147
               .||..|..:   |||||||:|.|.:..|| .|||||:|||||...|||  ..:....|..|.
  Rat   123 LEGMKETELTKLPMSEDCLYLNIYVPAHAHEDSNLPVMVWIHGGGLVGGSA--SMNDASTLAATE 185

  Fly   148 KVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGIS 212
            ::|:|::.||||..||.||||:|..||:|:.||..||:|:|::||.|||:...||:.|.||||.|
  Rat   186 EIVIVSIQYRLGVLGFFSTGDQHARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTS 250

  Fly   213 AHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELA-IDQAESLSSQDLAEALR 276
            ...|::||.|||||..::..:|...|..  ::.|   .:..:.|.:| :...|:..|:.|...||
  Rat   251 VSSHVVSPMSKGLFHRAIMQSGVALLPG--LISD---TSEVVYKTVANLSGCEASDSEALIRCLR 310

  Fly   277 NVCPKKLLVSVDSLKVWDNMPHLTTLP-VLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSS-R 339
            ....:::|......|:         :| |::.    .||.:.|.:...:...:.:|.|:.::: .
  Rat   311 AKSKQEILAINQVFKM---------IPGVVDG----KFLPKHPQELLASKDFHPVPSIIGVNTDE 362

  Fly   340 AGEGSLFIMRAF--INPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTM 402
            .|.|...|:..:  || .:..|.....|:..|..:.||.    :.:..|::.|  .||:.:.:|:
  Rat   363 CGWGVPTILGLYHIIN-NITRETLPAALKIAAAQMMLPP----ECIDLIMEEY--MGDTEDAETL 420

  Fly   403 -LKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITK----FFAGTTDDYGL 462
             .:..|:.|||.|..|..:.       |:.:.:...:|.:||..|.|..|    |:.
  Rat   421 QAQFKEMLGDFIFVIPALQV-------AHFQRSQAPVYFYEFQHLLSFIKQVRPFYP-------- 470

  Fly   463 GAVHMDDGLHTIRIPVSF---DDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESI--CKVSDFKE 522
            .|.|.||   |:.:..|:   ..|....|:..:.:|:.....:||:||..:.|.:  ..|.|..|
  Rat   471 KADHGDD---TVFVFGSYFWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDE 532

  Fly   523 Q 523
            |
  Rat   533 Q 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	159/499 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/104 (49%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	166/521 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840