Protein Alignment Jhedup and Aadac

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_075872.1
• Gene: Aadac / 67758
• MGIID: 1915008
• Length: 398
• Species: Mus musculus
• Alignment Length: 461
• Identity: 93/461 - (20%)
• Similarity: 159/461 - (34%)
• Gaps: 179/461 - (38%)

  Fly    64 PVPN---EPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVE-------------------------- 99
            |:|:   |||:.|.:....|......|:    ..|:|:.
Mouse    21 PLPDAIEEPWKVVWETAFVKIGTDLASF----GELLGISHFMETIQLLMSFQEVPPTSDEHVTVM 81

  Fly   100 ----DCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDT------NKV--VMV 152
                |.:.:.:|.||.::......:.||||||:..|||      ..:..||      :|:  |:|
Mouse    82 ETAFDSVPVRIYIPKRKSMALRRGLFYIHGGGWCLGSA------AHFSYDTLSRWTAHKLDAVVV 140

  Fly   153 TMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKH--IATFGGDPKKVTVLGHSAGG----- 210
            :.:|.|.|       ..|.|..  |:|...:|:|..:.  :..:|.||::|.|.|.||||
Mouse   141 STDYGLAP-------KHHFPRQ--FEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAA 196

  Fly   211 ISAHL-------------HMISPNSKGLFQNSMS---------LTGTMFLSAMKILKDPLSQARR 253
            ::..|             .:|.|..:.|..|..|         ||.::.   ::...:..:..|.
Mouse   197 VTQQLIQDPDVKIKLKVQALIYPALQALDTNVPSQQEGSHFPVLTRSLM---VRFWSEYFTTDRG 258

  Fly   254 LGKELAIDQAESLSSQDLAEALR--NVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVE 316
            |.|.:.::|...:.|..|.:.:.  ::.|::...|                ||.:.|:|
Mouse   259 LEKAMLLNQHVPMESSHLLQFVNWSSLLPERYKKS----------------PVYKNPTP------ 301

  Fly   317 DPLDAHRAGRINQMPWILSLSSRAGEGSLFIMR---AFINPK---LRAEFNENFLEHMALLLNLP 375
                                      ||..:.:   .||:.|   |.|  |:|.|.|:
Mouse   302 --------------------------GSSELAQKYPGFIDVKACPLLA--NDNILHHL------- 331

  Fly   376 EGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYI 440
               |...:  |...||.    |.:|.::           |....:.:..:||:.::|:.  |...
Mouse   332 ---PKTYI--ITCQYDV----LRDDGLM-----------YVKRLQNVGVHVTHHHVEDG--FHGT 374

  Fly   441 FEFAGL 446
            |.|.||
Mouse   375 FSFPGL 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	93/461 (20%)
Aadac	NP_075872.1	Abhydrolase_3	106..356	CDD:400284	71/344 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)