Protein Alignment Jhedup and NLGN2

DIOPT Version :9

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 161/603 - (26%)
• Similarity: 250/603 - (41%)
• Gaps: 148/603 - (24%)

  Fly    41 GEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV------- 98
            |....|:|:|:|.||:|..|.:.|.....|.||.:|.....:|.|..:.|....::.|
Human    64 GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLE 128

  Fly    99 ----------EDCLYLNVYRP-------KNRAE-------------DKLPVMVYIHGGGFFSGSA 133
                      |||||||:|.|       |.|.|             .|.|||:::|||.:..|:.
Human   129 AAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTG 193

  Fly   134 HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDP 198
            : |..| ..|.....|::.|:|||||..|||||||:...||:|..||..||:|:.::||.|||||
Human   194 N-MFDG-SVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDP 256

  Fly   199 KKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQA 263
            :::|:.|..||....:|.::|.:|:||||.:::.:||. :|:..:...||...|.|..::..|:.
Human   257 ERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA-ISSWSVNYQPLKYTRLLAAKVGCDRE 320

  Fly   264 ESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAP-SPDAFLVEDPLDAHRAGRI 327
            :   |.:..|.||.. |.:.||..|   |.....|:...||::.. .||     ||....:.|..
Human   321 D---SAEAVECLRRK-PSRELVDQD---VQPARYHIAFGPVVDGDVVPD-----DPEILMQQGEF 373

  Fly   328 NQMPWILSLSSRAGEGSLFI-----------MRAFINPKLRAEFN-ENFLEHMALLLNLPEGTPV 380
            .....::.::.  |||..|:           ..||       :|. .||:::   |...|||..|
Human   374 LNYDMLIGVNQ--GEGLKFVEDSAESEDGVSASAF-------DFTVSNFVDN---LYGYPEGKDV 426

  Fly   381 QMVSEIL-----DAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYI 440
              :.|.:     |..|.....:...|:|.|..   |..:..|...|...:..|    ::|::.|.
Human   427 --LRETIKFMYTDWADRDNGEMRRKTLLALFT---DHQWVAPAVATAKLHADY----QSPVYFYT 482

  Fly   441 F----------EFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPV--SFDDFPKD--SEDAK 491
            |          |:|                  .|.|.|:..:...:|:  :.|.||.:  ..|..
Human   483 FYHHCQAEGRPEWA------------------DAAHGDELPYVFGVPMVGATDLFPCNFSKNDVM 529

  Fly   492 VIQRMSSLMTDFAKTG-----------VFH------EESICKVSDFKEQGMCNYLHFGGNKEKYL 539
            :...:.:..|:|||||           ..|      ||.:....:.||:   .|||.|....
Human   530 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEK---QYLHIGLKPR--- 588

  Fly   540 EDIRNSITLTAFPIWKKL 557
              :|::........|.:|
Human   589 --VRDNYRANKVAFWLEL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	149/546 (27%)
		Aes	<106..>210	CDD:223730	48/123 (39%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	159/598 (27%)
		Aes	<170..>268	CDD:223730	43/99 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740