Protein Alignment Jhedup and NLGN4X

DIOPT Version :9

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 176/641 - (27%)
• Similarity: 263/641 - (41%)
• Gaps: 143/641 - (22%)

  Fly     8 VLLFV-AVAVGDSL-------DVCLEDMGCMRG--TLMPGYQSGEFEAFMGIPFAQPPVGPLRLK 62
            |||:: |:|:..:|       .|...:.|.:||  |.:|....|..|.::|:|:|.||.|..|.:
Human    25 VLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQ 89

  Fly    63 NPVPNEPWEGVLDAGAAKDSCIQ----RS---------YFAKEWGLMGV-----EDCLYLNVYRP 109
            .|.|...|.|:.:.......|.|    ||         :.|....||..     |||||||:|.|
Human    90 PPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVP 154

  Fly   110 --------KN--------RAED--------KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVV 150
                    ||        |.||        |.|||||||||.:..|:.: |..| ..|.....|:
Human   155 TEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEGTGN-MIDG-SILASYGNVI 217

  Fly   151 MVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHL 215
            ::|:|||||..|||||||:...||:|..||..||:||::::..||||||:||:.|..||.....|
Human   218 VITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSL 282

  Fly   216 HMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCP 280
            ..:|..|:||||.::..:||. ||:..:...|....|.|..::..:.   |.:.|:.|.|||...
Human   283 LTLSHYSEGLFQKAIIQSGTA-LSSWAVNYQPAKYTRILADKVGCNM---LDTTDMVECLRNKNY 343

  Fly   281 KKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSL 345
            |:|:....:...:    |:...||::..    .:.:||......|..  :.:.:.|....|||..
Human   344 KELIQQTITPATY----HIAFGPVIDGD----VIPDDPQILMEQGEF--LNYDIMLGVNQGEGLK 398

  Fly   346 FI-----MRAFINPKLRAEFN---ENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTM 402
            |:     ....:.|.   :|:   .||:::   |...|||... :...|...|....|..|.:|.
Human   399 FVDGIVDNEDGVTPN---DFDFSVSNFVDN---LYGYPEGKDT-LRETIKFMYTDWADKENPETR 456

  Fly   403 LK-LAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVH 466
            .| |..:..|..:..|...|...:..|.    :|.:.|.|.....:.:...:|
Human   457 RKTLVALFTDHQWVAPAVATADLHAQYG----SPTYFYAFYHHCQSEMKPSWA------------ 505

  Fly   467 MDDGLHTIRIPVSFD------------DFPKDSEDAKVIQRMSSLMTDFAKTG------------ 507
              |..|...:|..|.            :|.|:  |..:...:.:..|:|||||
Human   506 --DSAHGDEVPYVFGIPMIGPTELFSCNFSKN--DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF 566

  Fly   508 ------VFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWKKL 557
                  .|.|.:..|.:. |:|   .|||.|....     :|:....|....|.:|
Human   567 IHTKPNRFEEVAWSKYNP-KDQ---LYLHIGLKPR-----VRDHYRATKVAFWLEL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	155/559 (28%)
		Aes	<106..>210	CDD:223730	54/127 (43%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	168/619 (27%)
		Aes	<179..>286	CDD:223730	49/108 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740