DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and ces2b

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	584	Identity:	180/584 - (30%)
Similarity:	270/584 - (46%)	Gaps:	122/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AGFGVLLFVAVAVGDSL-----DVCLEDMGCMRGTLMPGY-QSGEFEAFMGIPFAQPPVGPLRLK 62
            |...:.:.:||.:.:|:     .:...:.|.::|..|... :.....:::|||||:||||||||.
Zfish     7 AVLSLCILIAVTLQNSVKAEDGPILQTNSGALKGLQMKARGKDTVIHSYLGIPFAKPPVGPLRLA 71

  Fly    63 NPVPNEPWEGVLDAGAAKDSCIQ---------RSYFAKEWGLMGVEDCLYLNVYRP-KNRAEDKL 117
            .|.|.|.||||.||......|:|         .:..||...:...|||||||||.| |....|||
Zfish    72 PPQPAEKWEGVRDATKQPLMCLQDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYTPSKPGRNDKL 136

  Fly   118 PVMVYIHGGGFFSGSA-----HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGF 177
            ||||:||||||.:.||     |.:|:..:       ||:|.:.||||..||.|||||:.|||:|.
Zfish   137 PVMVWIHGGGFTTCSASLFDGHVLAAYQD-------VVVVVIQYRLGLLGFFSTGDENAPGNYGL 194

  Fly   178 KDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMK 242
            .||..||||:|::|.:|||||..||:.|.||||||..||::||.|..||..:::.:||..:.|:.
Zfish   195 LDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAESGTAAMEAIM 259

  Fly   243 ILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHL---TTLPV 304
            .: :||..|:.:|.....|.:   |::.:.:.|....      .|:.||:....|..   .|:..
Zfish   260 NV-NPLPIAQAIGNASGCDIS---STKKIVDCLMQKS------EVEILKITMENPLFRFGVTIDG 314

  Fly   305 LEAPSPDAFLVEDPLDAHRAGRINQMP----------------------WILSLSSRAGEGSLFI 347
            ...|.|.|.|.:       :.:.|::|                      ||..|..   |..|.:
Zfish   315 QFLPRPAAELFQ-------SQQFNKVPLMTGVTDDEIGFVLPNYLLPPDWINGLDL---ESILPL 369

  Fly   348 MRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDF 412
            :..| ||.|:   :::.||   ||||...||....: .|.|.:               .|:.|||
Zfish   370 LTVF-NPALQ---DQSVLE---LLLNEYLGTSPDRI-RIRDGF---------------REMLGDF 411

  Fly   413 NFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITK----FFAGTTDDYGLGAVHM-----D 468
            .|..|..:| :||...|...     :|::||....|:.:    .|:|:  |:|...|.:     .
Zfish   412 MFNIPARQT-ASYHRDAGAP-----VYVYEFRHPPSVLQRKRPSFSGS--DHGDEIVFVFGYCFS 468

  Fly   469 DGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFG 532
            :|      |:...:...|.|| ::.:...:...:||.||..:...:....:|.::  ..||..|
Zfish   469 EG------PIGMAENLSDEED-ELCRTTMAYWGNFAHTGNPNGPGLTSWPEFGDE--AEYLSIG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	170/526 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	57/109 (52%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	176/564 (31%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920