Protein Alignment Jhedup and nlgn4xa

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 624
• Identity: 165/624 - (26%)
• Similarity: 259/624 - (41%)
• Gaps: 125/624 - (20%)

  Fly    11 FVAVAVGDSLDVCLEDMGCMRG--TLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGV 73
            ::|:.......:...:.|.:||  |.:|....|..|.::|||:|.||.|..|.:.|.|...|.|:
Zfish    33 WLAITWAQQHPIVTTNYGKLRGLKTPLPNEILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGI 97

  Fly    74 LDAGAAKDSCIQRSYFAKEWGLMG---------------------VEDCLYLNVYRP-----KNR 112
            .:|......|.|   |.::..|:.                     .|||||||:|.|     .|:
Zfish    98 RNATQFAPVCPQ---FLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVGANK 159

  Fly   113 AED-----------------KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGP 160
            .:|                 ..|||||||||.:..|:.: |..| ..|.....|::||:|||||.
Zfish   160 GDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGN-MIDG-SILASYGNVIVVTLNYRLGV 222

  Fly   161 FGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGL 225
            .|||||||:...||:|..||..||:||:::|..|.||||:||:.|..||.....|..:|..|:.|
Zfish   223 LGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDL 287

  Fly   226 FQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVS-VDS 289
            ||.::..:||. ||:..:...|....|.|.:::..:..:|:   ||.|.|:|...|:|:.. :..
Zfish   288 FQKAIIQSGTA-LSSWAVNYQPAKYTRILAEKVGCNMLDSI---DLVECLQNKNYKELIEQYITQ 348

  Fly   290 LKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINP 354
            .|.     |:...||::..    .:.:||......|..  :.:.:.|....|||..|: ...::.
Zfish   349 AKY-----HIAFGPVIDGD----VIPDDPQILMEQGEF--LNYDIMLGVNQGEGFKFV-DGIVDS 401

  Fly   355 KLRAEFNE------NFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLK-LAEISGDF 412
            :.....|:      :|::|   |...|||... :...|...|....|..|.:|..| |..:..|.
Zfish   402 EDGVSANDFDFAVSDFVDH---LYGYPEGKDT-LRETIKFMYTDWADKENPETRRKTLVALFTDH 462

  Fly   413 NFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIP 477
            .:..|...|...:..|.    :|.:.|.|.....:.:...::        .:.|.|:..:...||
Zfish   463 QWVAPAVATADLHAQYG----SPTYFYAFYHHCQSEMKPSWS--------DSAHGDEVPYVFGIP 515

  Fly   478 V-----SFD-DFPKDSEDAKVIQRMSSLMTDFAKTG------------------VFHEESICKVS 518
            :     .|: :|.|:  |..:...:.:..|:|||||                  .|.|.:..|.:
Zfish   516 MLGPTDLFNCNFSKN--DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYN 578

  Fly   519 DFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWKKL 557
            . |:|   .|||.|....     :|:....|....|.:|
Zfish   579 P-KDQ---LYLHIGLKPR-----VRDHYRATKVAFWLEL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	150/553 (27%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	162/609 (27%)