Protein Alignment Jhedup and nlgn2a

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_009301340.1
• Gene: nlgn2a / 556158
• ZFINID: ZDB-GENE-090918-2
• Length: 828
• Species: Danio rerio
• Alignment Length: 626
• Identity: 161/626 - (25%)
• Similarity: 251/626 - (40%)
• Gaps: 164/626 - (26%)

  Fly    41 GEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV------- 98
            |..|.::|:|:|..|:|..|.:.|.....|:.|.:|......|.|..:......::.|
Zfish    69 GPVEQYLGVPYATAPIGDRRFQPPEAPGSWQEVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSLD 133

  Fly    99 ----------EDCLYLNVYRPK--------------NRAED-------KLPVMVYIHGGGFFSGS 132
                      |||||||||.|.              ||..|       |.|||::||||.:..|:
Zfish   134 VAATYIQNQSEDCLYLNVYVPTEDGPLTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGT 198

  Fly   133 AHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGD 197
            .:...:  ..|.....|::||||||||..|||||||:...||:|..||..||:|:.::|..||||
Zfish   199 GNMFDA--SVLAAYGNVIVVTMNYRLGVLGFLSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGD 261

  Fly   198 PKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQ 262
            |:::|:.|..||....:|.::|.:|:||||.:::.:|:. :|:..|...||...:.|.:::....
Zfish   262 PERITIFGSGAGASCVNLLILSHHSEGLFQRAIAQSGSA-ISSWSISYQPLKYTKILARKVGCTY 325

  Fly   263 AESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMP---HLTTLPVLEAP-SPDAFLVEDPLDAHR 323
            .|   :.||.:.||.   |.....||.    |..|   |:...||::.. .||     ||....:
Zfish   326 GE---TADLVDCLRR---KNFRELVDQ----DIQPARYHIAFGPVMDGDVVPD-----DPEILMQ 375

  Fly   324 AGRINQMPWILSLSSRAGEGSLFIMRAFINPK---LRAEFN---ENFLEHMALLLNLPEGTPVQM 382
            .|..  :.:.|.:....|||..|:.......:   ..|.|:   .||:::   |...|:|..:
Zfish   376 QGEF--LNYDLLIGVNQGEGLKFVDDGGTESEEGISAAAFDYTISNFVDN---LYGYPKGKDI-- 433

  Fly   383 VSEIL-----DAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIF- 441
            :.|.:     |..|.....:...|:|.|..   |..:..|...|...:..|    ::|::.|.|
Zfish   434 LRETIKFMYTDWADRDNGEMRRKTLLALFT---DHQWVAPAIATAKLHADY----QSPVYFYTFY 491

  Fly   442 ---------EFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPV--SFDDFPKD--SEDAKVI 493
                     |:|                  .|.|.|:..:...:|:  :.|.||.:  ..|..:.
Zfish   492 HHCQTETRPEWA------------------DAAHGDEIPYVFGVPMIGATDLFPCNFSKNDIMLS 538

  Fly   494 QRMSSLMTDFAKTG-----------VFH------EESICKVSDFKEQGMCNYLHFG--------- 532
            ..:.:..|:|||||           ..|      ||.|....:.|::   .|||.|
Zfish   539 AVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRFEEVIWTKFNSKDK---QYLHIGLKPRIRDNY 600

  Fly   533 -GNKEKY-------LEDIRNSITLTA----------FPIWK 555
             .||..:       |.::...:..||          .|.||
Zfish   601 RANKVAFWLELVPHLHNLHEEVFSTATTRLPPGTARTPHWK 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	144/544 (26%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:395084	155/591 (26%)