Protein Alignment Jhedup and NLGN3

DIOPT Version :9

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 162/624 - (25%)
• Similarity: 250/624 - (40%)
• Gaps: 139/624 - (22%)

  Fly    28 GCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFA 90
            |.:||..  :|....|..:.::|:|:|.||:|..|...|.|...|.|:.:|......|.|..:.|
Human    49 GKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTA 113

  Fly    91 KEWGLMGV-----------------EDCLYLNVYRP---------------------------KN 111
            ....::.|                 |||||||||.|                           |.
Human   114 VPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKK 178

  Fly   112 RAED----------------KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGP 160
            :.||                ..|||||||||.:..|:.: |..| ..|.....|:::|:|||:|.
Human   179 QGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGN-MIDG-SILASYGNVIVITLNYRVGV 241

  Fly   161 FGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGL 225
            .|||||||:...||:|..||..||:|:.::||.|||||:::||.|...|.....|..:|.:|:||
Human   242 LGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGL 306

  Fly   226 FQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSL 290
            ||.::..:|:. ||:..:...|:.....|..::.   ...|.:.|:.:.||....|:|:..
Human   307 FQRAIIQSGSA-LSSWAVNYQPVKYTSLLADKVG---CNVLDTVDMVDCLRQKSAKELVEQ---- 363

  Fly   291 KVWDNMP---HLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFI 352
               |..|   |:...||::..    .:.:||......|..  :.:.:.|....|||..|: ...:
Human   364 ---DIQPARYHVAFGPVIDGD----VIPDDPEILMEQGEF--LNYDIMLGVNQGEGLKFV-EGVV 418

  Fly   353 NPK---LRAEFN---ENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLK-LAEISG 410
            :|:   ...:|:   .||:::   |...|||... :...|...|....|..|.:|..| |..:..
Human   419 DPEDGVSGTDFDYSVSNFVDN---LYGYPEGKDT-LRETIKFMYTDWADRDNPETRRKTLVALFT 479

  Fly   411 DFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIR 475
            |..:..|...|...:..|.    :|.:.|.| :....|:.|  ...:|     |.|.|:..:...
Human   480 DHQWVEPSVVTADLHARYG----SPTYFYAF-YHHCQSLMK--PAWSD-----AAHGDEVPYVFG 532

  Fly   476 IPV--SFDDFPKD--SEDAKVIQRMSSLMTDFAKTG-----------VFHEESICKVSDFKEQGM 525
            :|:  ..|.||.:  ..|..:...:.:..|:|||||           ..|    .|.:.|:|...
Human   533 VPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIH----TKANRFEEVAW 593

  Fly   526 CN-------YLHFGGNKEKYLEDIRNSITLTAFPIWKKL 557
            ..       |||.|....     :|:....|....||.|
Human   594 SKYNPRDQLYLHIGLKPR-----VRDHYRATKVAFWKHL 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	148/563 (26%)
		Aes	<106..>210	CDD:223730	50/146 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	159/619 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740