DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Cesl1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	165/605 - (27%)
Similarity:	264/605 - (43%)	Gaps:	103/605 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VGDSLD-------VCLEDM--------------------GCMRGTLMPGYQSGE-----FEAFMG 48
            |.||:|       :||..:                    ..|:|.::..|.|.|     ...|:|
  Rat    23 VRDSIDWSICPRKMCLRSLFLVSLATCVVCGNPSSPPVVDTMKGKVLGKYASLEGVTQSVAVFLG 87

  Fly    49 IPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWG-----------LMGVEDCL 102
            :|||:||:|.||...|.|.|||..|.:.......|.|.:...:...           |...||||
  Rat    88 VPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDATKGQRMNDLLTNRKEKVHLQFSEDCL 152

  Fly   103 YLNVYRPKNRAED-KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLST 166
            |||:|.|.:..:| ::||||:|||||...|.|.....  :.|.....||:|.:.||||.:||.||
  Rat   153 YLNIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDG--QVLSAYENVVVVAIQYRLGIWGFFST 215

  Fly   167 GDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMS 231
            ||||..||:|..||..||.|:|.:||.|||||..||:.|.||||.|..:.::||.||.|:..::|
  Rat   216 GDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAIS 280

  Fly   232 LTGTMFLSAMKILKDPLSQARRLGKELAIDQA--ESLSSQDLAEALRNVCPKKLLVSVDS---LK 291
            .:|.:.::.: ..||    .|...|::| |.|  ::.:|..:...||....::||..::.   :|
  Rat   281 ESGVVLITEL-FTKD----VRPAAKQIA-DMAGCKTTTSAIIVHCLRQKTEEELLEIMEKMNLIK 339

  Fly   292 VWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINP-- 354
            :........:...|.....|..|.:||.:.......|.:|:|:.::.:.....|..|..|:.|
  Rat   340 LSSQRDTKESYHFLSTVIDDVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMRFVPPDV 404

  Fly   355 KLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAE----ISGDFNFY 415
            ||..:.....||..|.:..:||    .::...::.|. ||    :|..:|:.:    ..||..|.
  Rat   405 KLDKKMAIMLLEKFASIYGIPE----DIIPVAIEKYR-KG----SDDPIKIRDGILAFIGDALFC 460

  Fly   416 YPIYETISSYVTYANLEEN-PLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVS 479
            .|     |..|:..:.:.. |.::|.:::      ...|:.......:...|.||.......|:.
  Rat   461 IP-----SVMVSRDHRDAGAPTYVYEYQY------YPSFSSPQRPKDVVGDHADDVYSVFGAPIL 514

  Fly   480 FDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLE---D 541
            .|.  ...|:.|:.:.:.....:||:.|           :...:|:.::..: ..||:||:   .
  Rat   515 RDG--ASEEEIKLSKMVMKFWANFARNG-----------NPNGRGLPHWPQY-DQKEEYLQIGAT 565

  Fly   542 IRNSITLTAFPI--WKKLFA 559
            .:.|..|.|..:  |.:|.|
  Rat   566 TQQSQGLKAEEVAFWTQLLA 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	146/505 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/104 (49%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	156/564 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100