DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces2h

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	164/561 - (29%)
Similarity:	253/561 - (45%)	Gaps:	99/561 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AGFGVLLFVAVAVGDSLD-VCLEDMGCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPV 65
            |..|:||.:.|...|||. :.....|.:.|:|  |.|...| ..:|:|||||:||:||||...|.
  Rat    13 AACGLLLLLQVQGQDSLSPIRTTHTGQILGSLIHMKGLDVG-VHSFLGIPFAKPPIGPLRFAPPE 76

  Fly    66 PNEPWEGVLDAGAAKDSCIQ--RSYFAKEWGLMGV--------EDCLYLNVYRPKNRAE-DKLPV 119
            ..|||.||.|..:....|:|  .:...:.:.|:.:        |||||||:|.|.:..| ..|||
  Rat    77 APEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSNLPV 141

  Fly   120 MVYIHGGGFFSGSAHPMAS--GPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRL 182
            ||:||||....|    |||  ....|.....||:||:.||||..||.||||:|..||:|:.||..
  Rat   142 MVWIHGGALVIG----MASLYDGSMLAAMENVVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQVA 202

  Fly   183 ALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAM-KILKD 246
            ||.|:|::||.|||:|.:||:.|.||||.|...|::||.|:|||..::..:|...:|:: .:..|
  Rat   203 ALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIMESGVALMSSLISVSSD 267

  Fly   247 -------PLSQARRLGKELAIDQAESLSSQDLA---EALRNVC-----------PKKLLVSVDSL 290
                   .||...::..:..::.....|.:::.   :|.|.:.           ||:||.|.|.
  Rat   268 VVYRTVANLSGCEQVDSKALVNCLRGKSEEEIMSINKAFRIISGIVDGIFLPRHPKELLASADF- 331

  Fly   291 KVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPK 355
                   |         |.|....|.:          ::..||:..|....:....:.|..:...
  Rat   332 -------H---------PIPSIIGVNN----------DEYGWIIPSSMTTTDSKKKMDRQMVQAI 370

  Fly   356 LRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTM-LKLAEISGDFNFYYPIY 419
            |:        :.:|.::..||      .|::| ..::.|||.:...: ::..|:..||.|..|..
  Rat   371 LQ--------KRVAQMMWPPE------FSDLL-LEEYMGDSEDPQFLQVQFKEMMEDFTFVIPAL 420

  Fly   420 ETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFP 484
            :.       |:.:.:...:|.:||....|   ||..:...: :.|.|.|:.|...|.........
  Rat   421 QV-------AHFQRSNAPVYFYEFQHRPS---FFKDSKPPH-VKADHGDEILFIFRSFWGGTQVD 474

  Fly   485 KDSEDAKVIQRMSSLMTDFAKTGVFHEESI--CKVSDFKEQ 523
            ...|:..:.:||.....:||:.|..:.|.:  ..|.|..||
  Rat   475 LTEEEELLSRRMMKYWANFARQGNPNSEGLPYWPVFDHDEQ 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	149/514 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/106 (49%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	156/544 (29%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	52/106 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840