DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ace

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	152/554 - (27%)
Similarity:	241/554 - (43%)	Gaps:	119/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSY---- 88
            |.:||..:. .|..|...:.|||:|:|||..||.:.|||.|||.|||||.....:|:|..|
  Fly    50 GPVRGRSVT-VQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFP 113

  Fly    89 -FAKE--W--GLMGVEDCLYLNVYRP----------KNRAE----------------------DK 116
             |:.|  |  .....|||||:||:.|          .|..|                      :.
  Fly   114 GFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNG 178

  Fly   117 LPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFL-------STGDEHMPGN 174
            ||::::|:||||.:|||.......:.:.....|::.:..||:|.||||       |...|..|||
  Fly   179 LPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGN 243

  Fly   175 FGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLS 239
            .|..||.||::|::.:...|||:|:.:|:.|.|||..|.:..::||.::||.:..|..:|||
  Fly   244 VGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTM--- 305

  Fly   240 AMKILKDPLS-----QARRLGKELAID---QAESLSSQ--DLAEALRNVCPKKLLVSVDSLKVWD 294
                 ..|.|     :|..:||.|..|   .|..|.:.  .:...:|:|..|.:     |::.|:
  Fly   306 -----NAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTI-----SVQQWN 360

  Fly   295 NMPHLTTLPVLEAPSPD-AFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFIN----- 353
            :...:.:.|  .||:.| |||..||:...:...:..  :.:.:.:...||:.|::..||:
  Fly   361 SYSGILSFP--SAPTIDGAFLPADPMTLMKTADLKD--YDILMGNVRDEGTYFLLYDFIDYFDKD 421

  Fly   354 -----PKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFN 413
                 |:      :.:||.|..:..  :.|..:..:.|.....::|:. ......::....||..
  Fly   422 DATALPR------DKYLEIMNNIFG--KATQAEREAIIFQYTSWEGNP-GYQNQQQIGRAVGDHF 477

  Fly   414 FYYPIYETISSYVTYAN-LEENPLFIYIFEFAGLNSITKFFAGTTDDYG--LGAVHMDDGLHTIR 475
            |..|..|       ||. |.|....::.:.|....|        |..:|  :|.:|.|:..:...
  Fly   478 FTCPTNE-------YAQALAERGASVHYYYFTHRTS--------TSLWGEWMGVLHGDEIEYFFG 527

  Fly   476 IPV--SFDDFPKDSEDAKVIQRMSSLMTDFAKTG 507
            .|:  |....|.:.|..|   ||.|.:.:|||||
  Fly   528 QPLNNSLQYRPVERELGK---RMLSAVIEFAKTG 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	151/551 (27%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	41/142 (29%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	152/554 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840