DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and alpha-Est1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	618	Identity:	179/618 - (28%)
Similarity:	280/618 - (45%)	Gaps:	132/618 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VAVAVGDSLD----------------------VCLEDMGCMRG----TLMPGYQSGEFEAFMGIP 50
            :.|.|||.|.                      ||..| |.:||    ||   |....:.||.|||
  Fly     3 IRVGVGDLLKMGTKLIGHKIVQYRLGTKQTKVVCTRD-GQVRGHRRRTL---YDEEMYFAFEGIP 63

  Fly    51 FAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAED 115
            |||||||.||.:.|.|..||.||.|....:...:|:.:....  :.|.|||||||||..:.|::.
  Fly    64 FAQPPVGELRFRAPQPPHPWLGVRDCTYPRAKPMQKHFVLSI--VEGSEDCLYLNVYSKRLRSDK 126

  Fly   116 KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHM--PGNFGFK 178
            .|||:|:|:||||..|.|......|:|.|..: ||:||.|||:|..||||..|..:  |||.|.|
  Fly   127 PLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQD-VVVVTFNYRVGALGFLSLADRDLDVPGNAGLK 190

  Fly   179 DQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKI 243
            ||.:||:||.::||.|.|||:.:||:|.|||..|.|..|.:..::|||..::..:|:||   .:.
  Fly   191 DQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMF---CEW 252

  Fly   244 LKDPLSQ-ARRLGKELAIDQAESLSSQDLAEALRNVCPKKL------LVSVDSLKVWDNMPHLTT 301
            ..:|..: |.||..:|....:|  :.:::...|:.....::      |||.:..:.:...|.
  Fly   253 ANEPSGRWAYRLACQLGYSGSE--NEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPF--- 312

  Fly   302 LPVLEAPSPDAFLVEDPL--DAHRA------GRINQMPWILSLSSRAGEGSLFIMRAFINPKLRA 358
            .||:|     .::..|.:  ..||.      |  |.:|.||..:|..|   ||..::.::.:
  Fly   313 TPVVE-----PYITRDCVLPRCHREMLPEAWG--NDLPLILGGNSFEG---LFSYQSTLHDE--- 364

  Fly   359 EFNENFLEHMALLL--NLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFN-------- 413
               |:.|....:|:  .:.|.:....:.::|  ..||.|:.::.|..::     :||
  Fly   365 ---EHMLSAFEVLIPREIREKSTQSHLKDLL--RQFKVDNFDDATRGRM-----EFNECLHILSV 419

  Fly   414 --FYYPIYETISSYVTYANLEENPLFIYIFEFAG--LNSITKFFAGTTDDYGLGAVHMDDGLHTI 474
              |::.|:.|:.:.:::|  ...|.::|.|:...  .|...:...|   .:..|..|.|| |..:
  Fly   420 KHFWHGIHRTVLARLSHA--PATPTYLYRFDVDSPHFNHFRQVMCG---KHVRGVSHADD-LSYL 478

  Fly   475 RIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESIC--------KVSDFKEQGMCNYLHF 531
            ...:..:...|.|.:.:.|||:..:...||:    ::...|        :..|.|...||  |:.
  Fly   479 FYHILANKVDKSSMEYQTIQRLVGMWVAFAR----NDNPNCPQIGPTTWEALDEKGPQMC--LNI 537

  Fly   532 GGNKEKYLEDIRNSITLTAFP------IWKKLF 558
            |    |.||.|       ..|      ||.:|:
  Fly   538 G----KQLEFI-------VLPESKQNRIWDRLY 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	155/511 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/105 (50%)
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	167/566 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	56/116 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440392
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800