DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	169/503 - (33%)
Similarity:	247/503 - (49%)	Gaps:	60/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKE 92
            |.:||.|:......:|.||.|||:|.||:|.||.|.|...:||.|:.|.......|:|.|...||
  Fly    17 GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVSTLTKE 81

  Fly    93 WGLMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYR 157
              :.|.|||||||: ..|....|.:|||||||||.|..|.:...|.||:|.|..| ||.:::.:|
  Fly    82 --VEGSEDCLYLNI-SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFMKEN-VVYISIGHR 142

  Fly   158 LGPFGFLSTGDE--HMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISP 220
            |||.||||..|.  .:|||.|.||..|||:||:.:.|.|.|||:::|:.|||:|.::..|.:.||
  Fly   143 LGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASP 207

  Fly   221 NSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLV 285
            .|:|||..::.|.|    .:|::.:.| ....||.|.|.. :.:::.||.| |.|....| .|:|
  Fly   208 QSEGLFHRAILLAG----FSMELNRLP-QMEYRLAKHLGY-EGDNVDSQVL-EFLLKADP-ALIV 264

  Fly   286 SVD-----SLKVWDNMPHLTTLPVLEAPS-PDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGS 344
            |.|     ..:...|||.   .|.:|:.| |:|.|:.:|:|..|....|::|.||..:|  |||.
  Fly   265 SADFFTPLEKRQGHNMPF---KPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANS--GEGM 324

  Fly   345 LFIMRAFINPKLRAEFNENFLEHMALLLNLPE-------------GTPVQMVSEILDAY-DFKGD 395
            .......:||....||..|           ||             |...|:...::..: :..|.
  Fly   325 SIFSFVKMNPSWLKEFQCN-----------PERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGH 378

  Fly   396 SLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEF--AGLNSITKFFAGTTD 458
            .|..|....|.|:. ...|.:.:...|.|.:||.   :.|.::|.|:|  ...|.....|.| .:
  Fly   379 ELTVDHTNGLVELF-THGFVHAMDRLIQSRLTYG---QAPTYLYRFDFDSPDFNFYRIRFMG-KE 438

  Fly   459 DYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKT 506
            ..|:|  |:|:..:..::|.:| ...|...:...|:|:.::...||.|
  Fly   439 QRGVG--HVDELGYIFKLPATF-KLDKSRPEFTAIRRLVAMFVQFAAT 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	168/500 (34%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/105 (48%)
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	169/503 (34%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	56/115 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440399
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800