DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	159/552 - (28%)
Similarity:	259/552 - (46%)	Gaps:	72/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VAVGDSLDVCLEDM---------------------GCMRGTLMPGYQSGEFEAFMGIPFAQPPVG 57
            :||.|.:.:.|..:                     |.::|..........:.:|.|||||:||||
  Fly     5 IAVADQMRIALNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVG 69

  Fly    58 PLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKLPVMVY 122
            .||.|.||..|.|..|......:....|.:...|:  :.|.|||||||||..:......|||:|:
  Fly    70 ELRFKAPVEPEHWSDVKRCTHVRAKPCQVNIVLKQ--VQGSEDCLYLNVYTRELHPHRPLPVLVW 132

  Fly   123 IHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHM--PGNFGFKDQRLALQ 185
            |:||||..|.|......|:|:| ...||:|.::||||..||||..||.:  |||.|.|||.:||:
  Fly   133 IYGGGFQMGEASRDLYSPDYIM-MEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALR 196

  Fly   186 WIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQ 250
            |::::...|||||..:||.|.||||.|.|..|::..:||||..::.::|:. |:........::.
  Fly   197 WVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSA-LAPWAQTPTHINW 260

  Fly   251 ARRLGKELAIDQAESLSSQDLAEALRNVCPKKLL-VSVDSLKVWDNMPHLTTL---PVLEAP--S 309
            ..||.:  |.......:.:|:...|:......:| |:.|.:.:.:....||..   |.:| |  :
  Fly   261 PYRLAQ--ATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIE-PYLT 322

  Fly   310 PDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFIN--PKLRAEFNENFLEHMALLL 372
            |...:.:.||:..|....|.:|.::..:|..|    .:|...:|  |:|..:..:  .|::|
  Fly   323 PHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEG----LLMFPEVNKWPELLCQLGD--CENLA--- 378

  Fly   373 NLPEGTPV---------QMVSEILDAYDFKGD-SLNNDTMLKLAEISGDFNFYYPIYETISSYVT 427
              |:...|         :.|.|:     :.|| :....|:|:.:::.....|::.|:.|:.|...
  Fly   379 --PQDAHVDEQQRKAFGKKVREL-----YFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAH 436

  Fly   428 YANLEENPLFIYIFEFAGLN-SITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAK 491
            :|.|.  |.|:|.|:|...: :|.:..  |......|..|.|| |..:....:.....:.:.:.|
  Fly   437 HAPLA--PTFLYRFDFDSKHFNIMRII--TCGRKVRGTCHADD-LSYLFYNAAAKKLKRRTAEFK 496

  Fly   492 VIQRMSSLMTDFAKTGVFHEESICKVSDFKEQ 523
            .|:|:.|::..||.:|..:...:|:  |.|||
  Fly   497 TIKRLVSMVVHFAISGDPNIPMVCQ--DEKEQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	148/497 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	49/105 (47%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	155/528 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	49/105 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440390
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790