DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	172/563 - (30%)
Similarity:	256/563 - (45%)	Gaps:	72/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKE 92
            |.:||........|.:.:|..||||:||||.||.|.|...|||:..||..:..|..:|...|.::
  Fly    56 GPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRK 120

  Fly    93 WGLMGVEDCLYLNVYRPKNRAEDKL-PVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNY 156
            :.  |.||||||||| .|:...||| ||||:|:|||:..|.|......|::.| :..||:||:.|
  Fly   121 YA--GSEDCLYLNVY-VKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDFFM-SKDVVIVTVAY 181

  Fly   157 RLGPFGFLSTGDE--HMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMIS 219
            |||..||||..|.  ::|||.|.|||.:||:|:|::|..||||...:|:.|.||||.|.|...:|
  Fly   182 RLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALS 246

  Fly   220 PNSKGLFQNSMSLTGTMFLSAMKILKDPLSQ------ARRLGKELAI-----DQAESLSSQDLAE 273
            |.::||...::.::|::..        |.:|      |.||.::|..     |:|       :.|
  Fly   247 PQTEGLIHKAIVMSGSVLC--------PWTQPPRNNWAYRLAQKLGYTGDNKDKA-------IFE 296

  Fly   274 ALRNVCPKKLLVSVDSLKVWDNMPHLTTL---PVLEAPSPDAFLVEDPLDAHRAGRINQMPWILS 335
            .||::...:::.:..::...|...|....   ||:|     .:..|..:.|.:...:.|..|...
  Fly   297 FLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE-----PYTTEHTVVAKQPHELMQNSWSHR 356

  Fly   336 LSSRAG----EGSLFIMRAFINPKLRAEFN--ENFLEHMALLLNLPEGTPVQMVSEILDAYDFKG 394
            :....|    ||.||.......|....|..  :|.|. ..|.|||..........::..|| |..
  Fly   357 IPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLP-SDLGLNLDPKLRENYGLQLKKAY-FGD 419

  Fly   395 DSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAG--LNSITKFFAGTT 457
            :..|...|:|..|:.....|::|||....:.|..::.   |.::|.|:...  .|:|.....|
  Fly   420 EPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSA---PTYLYRFDHDSKLCNAIRIVLCG-- 479

  Fly   458 DDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKE 522
             ....|..|.||..:.....:|....| ||.:.|||..|..:.|.||..|..:.|||..:.....
  Fly   480 -HQMRGVCHGDDLCYIFHSMLSHQSAP-DSPEHKVITGMVDVWTSFAAHGDPNCESIKSLKFAPI 542

  Fly   523 QGMCNY--LHFGGNKE----KYLEDIRNSITLTAFPIWKKLFA 559
            :.:.|:  |:.|...|    ..|:.|.        |:|...:|
  Fly   543 ENVTNFKCLNIGDQFEVMALPELQKIE--------PVWNSFYA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	158/501 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/106 (48%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	163/518 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	63/156 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440401
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.740