DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Est-P

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	155/557 - (27%)
Similarity:	270/557 - (48%)	Gaps:	54/557 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLFVAVAVGDSLDVCLE-DMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVP-NEPWE 71
            ||::|....::..:.:| ..|.:||.     .:|.:.::..||.|:.|.|.||.:.|.| :..|.
  Fly    12 LLWIAALESEADPLIVEITNGKIRGK-----DNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWT 71

  Fly    72 GVLDAGAAKDSCIQRSYFAKEWG-LMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHP 135
            .|.:|..:...|:|.:.|..|.. |||.||||.:::|:||.......||:|.:|||.|..||.
  Fly    72 DVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSG-- 134

  Fly   136 MASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKK 200
            ...|.:.:|....:::|.:::.|||.||.||||.|:|||:|.||||||||||:|:||.|||.|..
  Fly   135 SIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDN 199

  Fly   201 VTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAES 265
            :.::||||||.||||.::..:.|.|.:.::|::|.. |....|.:....:|..||:  .:....:
  Fly   200 IVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNA-LDPWVIQQGGRRRAFELGR--IVGCGHT 261

  Fly   266 LSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLE-APSPDAFLVEDPLDAHRAGRINQ 329
            ..|.:|.:.|::.....::.:|.|..|:..:|.....||:| :.:|||||.|||....::|:..|
  Fly   262 NVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQ 326

  Fly   330 MPWILSLSSRAGEGSLFIMRAFINPKLRAE-----FNENFLEHMALLLNLPEGTPVQMVSEILD- 388
            :||.::.::.  :|.....:.....||..|     .|:.:.:....||...:..  :.:.::.|
  Fly   327 VPWAVTYTTE--DGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAK--KTIKDMDDL 387

  Fly   389 AYDFKGDSLNN-----DTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNS 448
            ::|.:...|.:     ::...:..:..|..|...:...|..:..|.   ::|::.::::....:.
  Fly   388 SFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYG---KSPVYSFVYDNPTDSG 449

  Fly   449 ITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFA----KTGVF 509
            :.:..:..||.: .|.||.||................|.|  .:.::...::.|||    .|..|
  Fly   450 VGQLLSNRTDVH-FGTVHGDDFFLIFNTAAYRTGIRPDEE--VISKKFIGMLEDFALNDKGTLTF 511

  Fly   510 HEESICKVSDFKEQGMCNYLHFGGNKE-KYLEDIRNS 545
                          |.||:.:...:|| :.|...||:
  Fly   512 --------------GECNFQNNVNSKEYQVLRISRNA 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	141/494 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/103 (49%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	152/543 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	61/135 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440342
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890