Protein Alignment Jhedup and Ces3a

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 531
• Identity: 169/531 - (31%)
• Similarity: 250/531 - (47%)
• Gaps: 76/531 - (14%)

  Fly     8 VLLFVAVAVGDSLDVCLED--MGCMRGTLMPGYQSGE--FEAFMGIPFAQPPVGPLRLKNPVPNE 68
            :|:|....:|..:.....|  :|.:||..: |.:..:  ...|:||||||.|:||||...|:|.:
Mouse    22 LLIFPTTVIGPKVTQPEVDTPLGRVRGRQV-GVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQ 85

  Fly    69 PWEGVLDAGAAKDSCIQ--------RSYFAKEWGLMGV-EDCLYLNVYRPKN-RAEDKLPVMVYI 123
            |||||.||......|:|        |....::..:..: ||||.||:|.|.. .|.||.||||:|
Mouse    86 PWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWI 150

  Fly   124 HGGGFFSGS--AHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQW 186
            |||....||  :|..::...|    ..||:||:.||||.||||||||:|||||.||.|...||:|
Mouse   151 HGGSLLVGSSTSHDGSALAAY----GDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRW 211

  Fly   187 IQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKD--PLS 249
            :|.:||.|||||..||:.|:|||||.....::||.|.|||..::|.:|.:.   .|||:|  ..|
Mouse   212 VQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVI---SKILEDLNAWS 273

  Fly   250 QARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFL 314
            :|:.....:|...|   |..:|.:.|.....|.|:...:.     |:.:...         |:|.
Mouse   274 EAQNFANSVACGSA---SPAELVQCLLQKEGKDLITKKNV-----NISYTVN---------DSFF 321

  Fly   315 VEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLE-------HMALLL 372
            .:.|.......:...:|::|.:::.. .|.|.:....|..|:.....|:.||       ||.|
Mouse   322 PQRPQKLLANKQFPTVPYLLGVTNHE-FGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQL-- 383

  Fly   373 NLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLF 437
                  |.:::..::|.|...| |..:.|...|.|:.||.....|.. ..|.|:..|..   |:|
Mouse   384 ------PPEIMPTVIDEYLDNG-SDESATRYALQELLGDITLVIPTL-IFSKYLQDAGC---PVF 437

  Fly   438 IYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDD-----FPKDSEDAKVIQ-RM 496
            :|.|:... :|..||     ....:.|.|..:.......|...|:     ||:.:|:.|.:. .|
Mouse   438 LYEFQHTP-SSFAKF-----KPAWVKADHSSENAFVFGGPFLTDESSLLAFPEATEEEKQLSLTM 496

  Fly   497 SSLMTDFAKTG 507
            .:..:.||:||
Mouse   497 MAQWSQFARTG 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	164/506 (32%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:395084	166/517 (32%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571