DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces1b

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	573	Identity:	155/573 - (27%)
Similarity:	246/573 - (42%)	Gaps:	94/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RGTLMPGYQSGE-FE----AFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRS--- 87
            :|.::..|.|.| ||    .|:|:|||:||:|.||...|.|.|||..|.:|.:....|.|.:
Mouse    30 QGKILGKYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATSYPPMCSQDAVAV 94

  Fly    88 ------YFAKEWGL--MGVEDCLYLNVYRPKNRAEDK-LPVMVYIHGGGFFSG----------SA 133
                  ...|:..:  :..|||||||:|.|.:..:.. |||||:|||||..:|          ||
Mouse    95 QLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVMVWIHGGGLMTGGASLYNGLALSA 159

  Fly   134 HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDP 198
            |            ..||:||:.||||.:|..||||||..||:...||..||:|:|.:||.|||:|
Mouse   160 H------------ENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGNP 212

  Fly   199 KKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELA-IDQ 262
            ..|||.|.||||:|..:.::||.:|.||..::| ..::.|..:.|..|.:  |..|.:.:| :..
Mouse   213 DSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAIS-ESSVVLENIVITLDLV--ACDLSQMIATVSG 274

  Fly   263 AESLSSQDLAEALRNVCPKKLL---VSVDSLKVW-------DNMPHLTTLPVLEAP-SPDAFLVE 316
            ....||..:.:.||.....:||   |.::..||.       ||....|.:..:..| :|:..|.|
Mouse   275 CNDTSSTAMVQCLRQKTENELLEITVKLEVTKVGGAASAKKDNTSMSTVIDGVVLPKAPEEILAE 339

  Fly   317 DPLDA--HRAG-RINQMPWIL--SLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPE 376
            .....  :..| ...:..||:  .|.....||           |:..|.....|......||:.|
Mouse   340 KSFSTVPYIVGFNKQEFGWIIPTMLGDLLSEG-----------KMNEETASLLLRRFHSDLNISE 393

  Fly   377 GTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIF 441
                .::..:::.| .:|    .|...|..::..|  .:..::..|.:.:...:|.:..:..|::
Mouse   394 ----SLIPAVIEKY-LRG----TDDPAKKRDLLLD--MFSDVFFGIPAVLLSRSLRDAGVSTYMY 447

  Fly   442 EFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKT 506
            ||....|    |........:...|.|:......||:..:.  ...|:..:.:.:.....:||:.
Mouse   448 EFRYRPS----FVSDKRPQTVEGDHGDEIFSVFGIPLLKEG--TSEEETNLSKMVMKFWANFARN 506

  Fly   507 GVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWKKLFA 559
            |..:.|.:....::.|:.  .||..|...::     ...:.......|.:|.|
Mouse   507 GNPNGEGLPHWPEYDEKE--GYLQIGATTQQ-----AQRLKAEEVAFWTELLA 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	146/520 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/114 (45%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	152/566 (27%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	57/129 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850