DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and CG10339

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_611881.1	Gene:	CG10339 / 37854	FlyBaseID:	FBgn0034972	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	141/557 - (25%)
Similarity:	244/557 - (43%)	Gaps:	123/557 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFA-----QPPVGPLRLKNPVPNEPW 70
            ||.|...|:..:.:...|.:.||.:..:::...:|::||.:|     |||        .:...||
  Fly    23 FVPVQCVDAPFIHIPGNGVISGTYLKMFRTQNIKAYLGIRYAHARRFQPP--------DIELTPW 79

  Fly    71 EGVLDAGAAKDSC------------------IQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKL 117
            :|:.:|...:..|                  ||....|::......|:||||||:.|     |.|
  Fly    80 KGIFNATVFQPDCWQNAMPSVGKETEQILKIIQSDSSAQDAERKYEENCLYLNVFVP-----DGL 139

  Fly   118 P------VMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFG 176
            |      |:|:||.|.|.:||  |....|..|:...||::||.:|||..|||.:|.|....||:|
  Fly   140 PEINGYAVVVWIHSGDFSTGS--PADVEPFQLVFKQKVIVVTFSYRLNIFGFFTTDDGEAQGNYG 202

  Fly   177 FKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPN-SKGLFQNSMSLTGTMFLSA 240
            ..||..||.|::|:|..||||..::|::||.||.:|..|||.|.. |||.|..::.::|
  Fly   203 LMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSGEWSKGGFHKAIIMSG------ 261

  Fly   241 MKILKDPLSQARR-LGKELAIDQAESLSSQDLAEALRNVCPKK-------LLVSVDSLKVWDNMP 297
                 :|||..:. ...|.::||..|..:          ||::       .|..:|:.::.:|:|
  Fly   262 -----NPLSTVKMPYEYEGSLDQVSSTFA----------CPRRPTSMFIQCLKRIDAKRLSENLP 311

  Fly   298 HLTTLPVLE---APSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAE 359
            .::..||::   :.:...|:...|....:.|..:::|.|:.::..  |..|.:.:..::..:...
  Fly   312 QVSWGPVVDFGLSNTSYPFIENQPEILFKKGSYHRVPVIIGVTDM--EEVLTLFKDNLDTDISPS 374

  Fly   360 FNENFLEHMA------LLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAE---ISGDFNFY 415
            ..|.|...:|      |:.|....:..:::|:.:: :.:..||   ||..|.|.   ||.....:
  Fly   375 DLEGFYTDIAVTDMHKLVRNYEWCSNYELISDAIN-FMYANDS---DTDAKKANKHIISAHTEKF 435

  Fly   416 YPIYETISSYVTYANL--EENPLFIYIF---------EFAGLNSITKFFAGTTDDYGLGAVHMDD 469
            |     |:...|:|:|  .::.::.|:|         :.....|:.|:|               |
  Fly   436 Y-----ITPMQTFADLISNDSQVYSYLFRMRPRSVLQDLPSWISVPKYF---------------D 480

  Fly   470 GLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKT 506
            .:.....|...:.....|.|.|:...:.:|..:||||
  Fly   481 QIFVWGNPYMTNSVDWKSTDKKIADIIMTLWANFAKT 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	136/537 (25%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	46/109 (42%)
CG10339	NP_611881.1	COesterase	30..560	CDD:278561	138/550 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	4	3.810