DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Jhe

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	234/551 - (42%)
Similarity:	317/551 - (57%)	Gaps:	26/551 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVP 66
            |.||.|... .|:|..|.|.||...:||::||.:.||||..||||||||:|.||:|.||..||..
  Fly    15 LLAGPGPFC-AALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKV 78

  Fly    67 NEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSG 131
            .....|:.||.|.|..|||::|......:.|.|||||||||||:.| :..|||||||||||||.|
  Fly    79 MPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNVYRPEIR-KSALPVMVYIHGGGFFGG 142

  Fly   132 SAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGG 196
            ||.|..:||||.||:.:|::|||.|||||||||||.|..|.||||.|||.|||:|:|::|..|||
  Fly   143 SAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGG 207

  Fly   197 DPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAID 261
            ||::||:.|.||||::||:|::||.|.|||...:|::||..: ...|.:.||.|||.|.:...:.
  Fly   208 DPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANV-PFAIAEQPLEQARLLAEFADVP 271

  Fly   262 QAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTL-PVL-EAPSPDAFLVEDPLDAHRA 324
            .|.:||:..|.:|||.:...|||.:.|.||.|| :.|:|.. ||: |....||||...|:|....
  Fly   272 DARNLSTVKLTKALRRINATKLLNAGDGLKYWD-VDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQ 335

  Fly   325 GRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLP----EGTPVQMVSE 385
            |....:|  |.|.:..|||::.::....|..||..||..|.|.:..||..|    :....:|:..
  Fly   336 GMPTSIP--LLLGTVPGEGAVRVVNILGNETLRQSFNLRFDELLQELLEFPASFSQDRREKMMDL 398

  Fly   386 ILDAYDFKGD-SLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSI 449
            :::.| |:|. .:|..|:.....:..|..|..|:|.||...|.:.   .||:::|.|.:.|..|.
  Fly   399 LVEVY-FQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHT---PNPVYLYSFNYQGPLSY 459

  Fly   450 TKFF--AGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG-VFHE 511
            ...:  |..|..||:  ||.||.|:..|.|:.|.||.::|.:||||.........|||.| ..:.
  Fly   460 ASAYTSANVTGKYGV--VHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFAKFGKPRNS 522

  Fly   512 ESI--C--KVSDFKEQGMCNYLHFGGNKEKY 538
            ||:  |  :|...:..|:|:|..|....:.|
  Fly   523 ESLTPCSIEVLQSRPDGICDYHEFANAPDAY 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	213/486 (44%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	68/103 (66%)
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	217/497 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444998
Domainoid	1	1.000	183	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25795
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910