DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and CG12869

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	122/526 - (23%)
Similarity:	221/526 - (42%)	Gaps:	111/526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRS---YFAKEWGL 95
            :.|....|...||:|||:||.|:..||.....|:..:...|.|...:..|.|.:   |.....|.
  Fly    43 VFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGS 107

  Fly    96 M-----GVEDCLYLNVYRPKNRAE-DKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTM 154
            |     ..|||||||::.|::... .|||::|.:.|..|.........:|.:  :....:|:|::
  Fly   108 MPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLD--LAGEGIVVVSV 170

  Fly   155 NYRLGPFGFLSTGDEH--MPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHM 217
            .||...:|:||.|::|  :|||:|..|.::||:||:::...|||:|..:|:|||.:||  |.|.:
  Fly   171 QYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGG--APLAL 233

  Fly   218 ISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQ-------------ARRLGKELAIDQAESL--- 266
            ::     ..::|..:...:.:|...|:: .|.|             .::||.:....|...|
  Fly   234 VA-----TLEDSSQVKQLVLMSPGPIMR-ALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGC 292

  Fly   267 ----SSQDLAEALRNV------CPKKLLVSVDSLKVWDNMPHLTTLPVL--EAPSPDAFLVEDPL 319
                |.:||..|..:|      ..:..::..:.|.:...:.:.|..|||  ...:..|||.:..|
  Fly   293 LRRKSREDLLRAYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLPPVLLGITSNEGAFLQDYWL 357

  Fly   320 DAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVS 384
            |..|.|::                   .:..:||..|....       |..|.::.|.:..|:.:
  Fly   358 DVAREGQV-------------------ALHKYINHTLLPNV-------MRALESVGEESSTQLAA 396

  Fly   385 EILDAYDFKGDSLN----------NDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIY 439
            .....::.||:.::          ::::.:|.        |..|.|.::...:||         |
  Fly   397 IRWRYFNGKGEGVSHLLAGMQRLLSESLYELP--------YSRILELLNGTTSYA---------Y 444

  Fly   440 IFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPK---DSEDAKVIQRMSSLMT 501
            :|:    :|.:....|..:.:| ||.|..| |..:..|..|....:   ..|:.::.:::.....
  Fly   445 VFD----HSHSMDMRGRRNLFG-GASHSSD-LPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFA 503

  Fly   502 DFAKTG 507
            :|.|.|
  Fly   504 NFIKNG 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	122/526 (23%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	34/106 (32%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	122/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000