DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and CG5397

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	141/538 - (26%)
Similarity:	225/538 - (41%)	Gaps:	110/538 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQ-RSYFAKEWGLMGVEDCLYLNVYR 108
            :|:|:.:|:|||||||...|| .:...|..:|......||| ...|.:.  ::|.||||.||||.
  Fly    75 SFLGMHYAEPPVGPLRYSRPV-YKRLAGDFNATKHGPPCIQPHPQFPQR--IIGDEDCLLLNVYT 136

  Fly   109 PKNRAEDK-LPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMP 172
            |:...|.. |||.|:||.||:..|||....:.|   |.....::|...||||..|.:..|.:...
  Fly   137 PQMPDETTGLPVFVWIHPGGYRYGSAAQYDATP---MAQRGAIVVAPQYRLGSLGIMGDGTKQFD 198

  Fly   173 GNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSK--GLFQNSMSLTGT 235
            ||....|...||:|:..:|:.|||:||:|..:||.:|..||....:||.|:  |.....::::||
  Fly   199 GNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGT 263

  Fly   236 MFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLK--------- 291
            . ||...:.|:|:...:.:.|   |:...:.:..::...||:...:.::.:.|.::
  Fly   264 A-LSQYAMDKEPVQSVQEVAK---INGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRAL 324

  Fly   292 ---VWDNM---PHLTT------LPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGS 344
               :..|:   ||:.:      ||.|        :|.:|....::...:.:|.:..::......|
  Fly   325 VKGLTGNVGFQPHIESEDDGRALPSL--------IVGEPEQQLKSSNFSGIPLLTGVTKHETANS 381

  Fly   345 LFIMRAFINPKLRAEFN--ENFLEHMALLLN-------------------LPEGTPVQMVSEILD 388
            :.:      ..:...|.  |.||..::..||                   ||..|.| :...:.|
  Fly   382 VTV------ETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSV-LTPTLQD 439

  Fly   389 AYDFKGDSLNNDTML-KLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSI-TK 451
            .:... .:||.|.:| |:.|.:.|..|..|...|...:...|     |.|:|.||:.|..|. ..
  Fly   440 VWKVP-QALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLA-----PAFMYSFEYNGTKSKGIN 498

  Fly   452 FFAG------TTDDYGLGAVHMDDGLHTIRIPVSFD--DF---PKD------SEDAKVIQRMSSL 499
            |..|      |..|......|.|:      |...||  |.   |.:      :||.||...:..|
  Fly   499 FLKGLPIVSETAHDKPETVGHGDE------IGYMFDANDIFGNPMEETRLTSAEDLKVRNNLIDL 557

  Fly   500 MTDFA--------KTGVF 509
            :..||        |:.:|
  Fly   558 LVKFANKDKEEGGKSSIF 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	140/535 (26%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	39/104 (38%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	141/538 (26%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	69/184 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	6	5.910