DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and cel.1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	607	Identity:	158/607 - (26%)
Similarity:	264/607 - (43%)	Gaps:	114/607 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEF---EAFMGIPFAQPPVGPLRLK 62
            ||......:||:..|.|.||...|.:.|.::|   .....|.|   :.|.|||||.|   |.|.:
Zfish     3 MLGVFISAVLFLGTAQGASLGAVLTEGGMVQG---KSRSVGLFRYMDTFKGIPFAAP---PKRFE 61

  Fly    63 NPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNR-AEDKLPVMVYIHGG 126
            .||.:..|||||.....:..|:|.:..|.:  ::|.|||||||::.|:.| ....|||||:|:||
Zfish    62 KPVAHPGWEGVLKTTDYRKRCLQLNLLATD--VIGSEDCLYLNIWVPQGRTVSSNLPVMVFIYGG 124

  Fly   127 GFFSGSA-------HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLAL 184
            .|..|..       :.:..|.| :.|...|::||.|||:|..||:||||:.:|||:|..||..|:
Zfish   125 AFLLGGGQGANFLDNYLYDGEE-MADRGNVIVVTFNYRVGALGFMSTGDDGIPGNYGLWDQHAAI 188

  Fly   185 QWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLS 249
            .|:.::|..|||:|..:|:.|.|||..|.:..:|:|.:||:.:.::|.:| :.|....|.::|
Zfish   189 SWVHRNIKAFGGNPDNITLFGESAGAASVNFQIITPKNKGMIRRAISQSG-VALCPWAISRNP-- 250

  Fly   250 QARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDN-----MPHLTTLPVLEA-- 307
              |:..:|:|......:.| .:|:.|:...||.:.:: ..||:..:     :.:|...||::.
Zfish   251 --RQFAEEIATKVGCPIDS-GMADCLKRADPKAVTLA-GKLKLTSSPDAPIVHNLYLSPVIDGDF 311

  Fly   308 -PSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALL 371
             |.....|..:..|......:|.|.                                  .|:...
Zfish   312 IPDEPETLFGNAADIDYIAGVNDMD----------------------------------AHIFAT 342

  Fly   372 LNLPE------GTPVQMVSEILDAYD-----------FK------GDSLNNDTMLK-LAEISGDF 412
            :::|.      .|||:.|..:..|..           |:      ||..|.:.:.: :.|:..|:
Zfish   343 IDIPSINNALTTTPVEEVQALATALSRDRGQDAGIATFQEYTVNWGDKPNKEKVKQTVVELETDY 407

  Fly   413 NFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIP 477
            .|..|....:  |:...|.:....|.|:|..:....:...:        :||.|.|:..:....|
Zfish   408 MFLVPTQAAL--YLHTDNAKSARTFSYLFTESSRIPVFPLW--------MGADHADELQYVFGKP 462

  Fly   478 VS--FDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHE-ESICKVS--DFKEQGMCNYLHFGGNKEK 537
            .:  ...||:..:.:|.   |.:..::||:||..:: ||...|:  :|...|. .||.......|
Zfish   463 FATPLGYFPRHRDVSKY---MIAYWSNFAQTGDPNKGESKVPVTWPEFSNPGH-QYLDINNKMNK 523

  Fly   538 YLEDIRNSITLTAFPIWKKLFA 559
              .:::..:.......|..:||
Zfish   524 --NNVKQMLRTRLVYYWTTVFA 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	136/521 (26%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	45/111 (41%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	146/555 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750