DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and CG6414

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	176/534 - (32%)
Similarity:	269/534 - (50%)	Gaps:	65/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDS-----LDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPN 67
            :||.:.:...|.     |.|.|...|.:.|..:..:......||||:|:|:||:..||.:.|||.
  Fly    13 ILLCICIQWSDGRNSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPK 77

  Fly    68 EPWEGVLDAGAAKDS--CIQRSYFAKEWGLMGVEDCLYLNVYRPKN-RAEDKLPVMVYIHGGGFF 129
            .||||  :..|.||:  |:||..|.::..|.|.|||||||||.|:. |....|||||:.||||:.
  Fly    78 APWEG--ERLAIKDAPICLQRDPFRRDMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGWQ 140

  Fly   130 SGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATF 194
            .||......||::|:| :.:|:|:.|:||||.|||||.....|||.|.|||...|.|::.:||:|
  Fly   141 CGSGISSFYGPDFLLD-HDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASF 204

  Fly   195 GGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELA 259
            ||||..|||.|.||||.|...||:|..|:||....::.:||.|        :|.:|....|  :|
  Fly   205 GGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYF--------NPWAQPAHKG--VA 259

  Fly   260 IDQAESLSS----------QDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFL 314
            ..:|..|:.          .:..|.||....:.::.|:..:.|||..|.:...||:|.....|||
  Fly   260 AGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFL 324

  Fly   315 VEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFIN-PKLRAEFNENFLEHMALLLNLP--E 376
            ...|..|.:...: |:|  |.:.:.|.|| |....|.:| |:|.|||...|.:.:.::||..  :
  Fly   325 TVAPRQAAKPHGL-QLP--LMVGATAEEG-LLKTAALLNLPQLLAEFKSQFEQVLPVVLNYDHHD 385

  Fly   377 GTPVQMVSEILDAYDFKG----DSLNNDTMLKLAE----ISGDFNFYYPIYETISSYVTYANLEE 433
            .:..|.:::.::::.||.    |..|:..:..|..    ::|           |..|:.....:|
  Fly   386 DSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAG-----------IDEYLRLRMSQE 439

  Fly   434 N--PLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPK---DSEDAKVI 493
            :  |.::|:|:..|..|.|:.|.|..::: .||.|.::..:.  .|:..:.|..   ..:|.::.
  Fly   440 DVAPTYVYLFDHKGAASFTEIFKGGRNEF-YGACHAEELQYL--FPIGRELFVSAVPTQKDLELR 501

  Fly   494 QRMSSLMTDFAKTG 507
            :.|..|...|||||
  Fly   502 ELMLHLWVSFAKTG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	169/506 (33%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	53/104 (51%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	170/511 (33%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	67/146 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970