DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces5a

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	154/500 - (30%)
Similarity:	232/500 - (46%)	Gaps:	73/500 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEW--- 93
            |.|.|      ...|:|||||.||:||||..||.|..||..:.:|....:.|.|.    .||
  Rat    49 GRLEP------VNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQN----LEWLFI 103

  Fly    94 ---------GLMGV-EDCLYLNVYRPKNRAED--KLPVMVYIHGGGFFSGSAHPMASGPEYLMDT 146
                     ..:|| |||||||:|.|. .|.|  :||||::|.||||.:|||.......  |...
  Rat   104 YQNLLKVHYPKLGVSEDCLYLNIYAPA-YANDGSRLPVMMWIPGGGFETGSASIFDGSA--LAAY 165

  Fly   147 NKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGI 211
            ..|::||:.||||.|||.:|.::|.|||:.|:||..||||::::|..|||:|..||:.|.|||.|
  Rat   166 EDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGGSAGAI 230

  Fly   212 SAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAID--QAESLSSQDLAEA 274
            |....::||.|.|||..::..:|...:.::|...|.|..    |.::..|  :.....|:.|.:.
  Rat   231 SISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKH----GLQVVADVCKCNVSDSKVLLKC 291

  Fly   275 LRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSR 339
            ||.....:||......|.:..        |::.    :|..|:|::.........:|.|:.::::
  Rat   292 LREKSSLELLSLGQKTKAFTR--------VVDG----SFFPEEPMELLSQKTFKTVPSIIGVNNQ 344

  Fly   340 AGEGSLFIMRAFINPKLRAEFNEN-FLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTML 403
            .. |.:..||.  .|::....||: .|..:.:||::|.    |.:..:...| |.|.....|...
  Rat   345 EC-GYILPMRE--APEILFGSNESTALTLIHVLLHIPP----QYMHIVAKDY-FHGKHSLTDIRD 401

  Fly   404 KLAEISGDFNFYYPIYETISSYVTYANLEE--NPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVH 466
            .|.::.||..|..|      ..||..|..:  .|::.|.|:..     ...|..|...: :.|.|
  Rat   402 TLLDLFGDVFFVVP------GLVTARNHRDAGGPVYFYEFQHR-----PNCFQNTRPAF-VKADH 454

  Fly   467 MDDGLHTIRIPVSFDD---FPKDSEDAKVIQR-MSSLMTDFAKTG 507
            .|:.......|....|   |.:.:||.|::.| |.|...:||::|
  Rat   455 TDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	153/499 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	49/105 (47%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	153/499 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840