DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces1e

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	169/600 - (28%)
Similarity:	266/600 - (44%)	Gaps:	104/600 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGE-----FEAFMGIPFAQPPVGPLRLKNPVPN 67
            :|:|:|..........|..:..::|.::..|.|.|     ...|:|:|||:||:|.||...|.|.
  Rat     7 ILVFLAAFTAGGHPSSLPVVDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPA 71

  Fly    68 EPWEGVLDAGAAKDSCIQRSYFA-----------KEWGLMGVEDCLYLNVYRPKNRAE-DKLPVM 120
            |||..|.:..:....|.|.....           :...|...|||||||:|.|.:..: |:||||
  Rat    72 EPWSFVKNTTSYPPMCSQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDRLPVM 136

  Fly   121 VYIHGGGFFSGSAHPMASGPEYLMDTNK-VVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLAL 184
            |:|||||...|.|   ::.....:.|:: ||:|.:.||||.:||.||||||..||:|..||..||
  Rat   137 VWIHGGGLVLGGA---STYDGLALSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAAL 198

  Fly   185 QWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLS 249
            .|:|.:|..|||||..||:.|.||||.|..:.::||.:|.||..::|.:| :.|:|..:.|:
  Rat   199 HWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESG-VALTAGLVKKN--- 259

  Fly   250 QARRLGKELA-IDQAESLSSQDLAEALRNVCPKKLLVSV------------DSLKVWDNMPHLTT 301
             .|.|.:::| :...:|.:|..:...||....::||.:.            ||.:.:..:|  |.
  Rat   260 -TRPLAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPFVP--TV 321

  Fly   302 LPVLEAPS-PDAFLVEDPLDAHRAGRINQMPWILSLSSRA-GEGSLFIMRAFIN-----PKLRAE 359
            |..:..|. |:..|.|..        .|.:|:|:.::.:. |    :|:...:|     .||...
  Rat   322 LDGVVLPKMPEEILAEKD--------FNTVPYIVGINKQEFG----WILPTMMNYPPSDMKLDPM 374

  Fly   360 FNENFLEHMALLLNLP-EGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETIS 423
            ...:.|:..:.||||| |..||.:...:....|   ...|.|.:|   |:.||..|..|
  Rat   375 TATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDD---PDRNKDQLL---ELIGDVIFGVP------ 427

  Fly   424 SYVTYANLEENPLFIYIFEFAGLNSITKFFAGTT--DDYGLGAVHMDDGLHTIRIPVSFDDFPKD 486
            |.:......:.....|::||....|.:.....:|  .|:|      |:.......|:......|
  Rat   428 SVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVVGDHG------DEIYSVFGAPILRGGTSK- 485

  Fly   487 SEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGN-------KEKYLEDIRN 544
             |:..:.:.|.....:||:.|..:.:.:....::.::.  .||..|..       |||.:
  Rat   486 -EEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKE--GYLQIGATTQQAQKLKEKEV----- 542

  Fly   545 SITLTAFPIWKKLFA 559
                 ||  |.:|.|
  Rat   543 -----AF--WSELLA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	153/517 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/105 (49%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	162/576 (28%)
		Aes	43..>239	CDD:223730	83/198 (42%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010