DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces4a

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	176/595 - (29%)
Similarity:	273/595 - (45%)	Gaps:	110/595 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPV 65
            :|....|:|....|.|||:                      ....|:|:||:|||||..|...|.
  Rat    35 LLITKHGILQGKQVHVGDT----------------------PIRVFLGVPFSQPPVGTRRFAPPE 77

  Fly    66 PNEPWEGVLDAGAAKDSCIQRSYFAKEWG---------------LMGVEDCLYLNVYRPKNRAED 115
            |..||.|:.||.....||:|.|     ||               |...|||||||||.|.....|
  Rat    78 PPLPWNGIRDATTYPPSCLQES-----WGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGD 137

  Fly   116 K-LPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKD 179
            . |||||:..||.|..|||... .|.| |....|||:|.:.||||..||.|||:.|..||:|..|
  Rat   138 PLLPVMVWFPGGAFLVGSASTY-EGSE-LAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLD 200

  Fly   180 QRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKIL 244
            |..||:|:|::|..|||||..||:.|.|||.:|....::||.::|||..::|.:||..|... |.
  Rat   201 QIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTF-IT 264

  Fly   245 KDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPS 309
            .|||..|:::......|..   |::.:.:.|:.:..:|:::....:..:....|.....::...|
  Rat   265 HDPLKSAKKIAHLAGCDHN---STKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLS 326

  Fly   310 P--DAFLV-EDPLDAHRAGRINQMPWILSLSSRAGEGSL-FIMRAFINPKLRAEFNENFLEHM-- 368
            |  |..:. |||:.....|::..:|::|.::|...|.|| |:|:..:|.::   .|:|::..:
  Rat   327 PVVDGLVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRI---MNKNYITKLLW 388

  Fly   369 --ALLLNL-PEGTPV---QMVSEILDAYDFKGDSLNNDTMLK--LAEISGDFNFYYPIYETISSY 425
              ::|||: .|..|:   :.:|:.:..:|:|        |.:  |.::.||..|   :|.|:.:
  Rat   389 SCSILLNITEEQIPLVAREYLSDAISHHDWK--------MFRNHLIDLVGDATF---VYATLQA- 441

  Fly   426 VTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDS--- 487
            ..|.....:|:::|.|:......|.|    ...|   ||.|.|:..:....|     |.|.|
  Rat   442 ARYHRDAGSPVYLYEFKHHAPGIIVK----PRSD---GADHGDELSYLFGSP-----FSKGSSRG 494

  Fly   488 EDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLE---DIRNSITL- 548
            |:.:...:|.....:||.||           |..::.:..:..| ..:||||:   |.|..:.|
  Rat   495 EEKEFSLQMMKYWANFAHTG-----------DPNDRELPYWPRF-DKEEKYLQLDFDTRVGVKLR 547

  Fly   549 -TAFPIWKKL 557
             .....|::|
  Rat   548 EKQMTFWRRL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	157/509 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/104 (50%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	174/590 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850