DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and CES4A

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_011521323.1	Gene:	CES4A / 283848	HGNCID:	26741	Length:	628	Species:	Homo sapiens

Alignment Length:	579	Identity:	170/579 - (29%)
Similarity:	250/579 - (43%)	Gaps:	126/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLDVCL---EDMGCMR----------GTLMPGYQ----SGEFEAFMGIPFAQPPVGPLRLKNPVP 66
            ||.:||   ..:|.:.          |||. |.|    ....:.|:|:||::||:|.||...|.|
Human    31 SLTLCLMAQTALGALHTKRPQVVTKYGTLQ-GKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEP 94

  Fly    67 NEPWEGVLDA-----------------------GAAKDSCIQRSY------------FAKEWG-- 94
            .|||:|:.||                       .|...|.:|.|.            ..:.||
Human    95 PEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQL 159

  Fly    95 -------------LMGVEDCLYLNVYRPKNRAED-KLPVMVYIHGGGFFSGSAHPMASGPEYLMD 145
                         |...|||||||||.|.....| :|||||:..||.|..|:|.......  |..
Human   160 ASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYEGSD--LAA 222

  Fly   146 TNKVVMVTMNYRLGPFGFL----STGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGH 206
            ..|||:|.:.:|||.||||    .|.|.|..||:|..||..||:|:|::||.|||||..||:.|.
Human   223 REKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQ 287

  Fly   207 SAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDL 271
            |||.:|....|:||.:.|||..::|.:||. |..:.|..:||..|:::..   :......|:|.|
Human   288 SAGAMSISGLMMSPLASGLFHRAISQSGTA-LFRLFITSNPLKVAKKVAH---LAGCNHNSTQIL 348

  Fly   272 AEALRNVCPKKLLVSVDSLK-------------VWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHR 323
            ...||.:...|::...:.::             :|...|.:..:.:     ||     |||....
Human   349 VNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVDGVVI-----PD-----DPLVLLT 403

  Fly   324 AGRINQMPWILSLSSRAGEGSL-FIMRAFINPK-LRAEFNENFLEHMALLLNLPEGTPVQMVSEI 386
            .|:::.:|::|.:::......| :||:..:|.: :|.|.....|.....|||:.:.....:|.|.
Human   404 QGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNITKEQVPLVVEEY 468

  Fly   387 LD---AYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNS 448
            ||   .:|:|  .|.|    ::.:|..|..|.|...:| :.|...|.|   |:::|.||......
Human   469 LDNVNEHDWK--MLRN----RMMDIVQDATFVYATLQT-AHYHRDAGL---PVYLYEFEHHARGI 523

  Fly   449 ITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG 507
            |.|   ..||    ||.|.|:.......|.: .......|.|..:| |.....:||:||
Human   524 IVK---PRTD----GADHGDEMYFLFGGPFA-TGLSMGKEKALSLQ-MMKYWANFARTG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	165/564 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/108 (46%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	165/564 (29%)
CES4A	XP_011521323.1	Aes	<184..>291	CDD:223730	50/108 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850