DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	548	Identity:	139/548 - (25%)
Similarity:	215/548 - (39%)	Gaps:	135/548 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MGCMRG-TLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNE---PWEGVLDAGAAKDSCIQRS 87
            ||.:.| |::......:...|.||.:|:||||.||.:.||..|   .:.|  |....|..|.|..
pombe    20 MGVLHGLTVLDENGKEKCHRFTGIRYAKPPVGKLRWRRPVTLEDGYDYSG--DYNQFKTICPQPF 82

  Fly    88 YFAKEWGLMGV-----EDCLYLNVYRPK-NRAEDKLPVMVYIHGGGFFSGS-AHPMASGPEYLM- 144
            |..::..:...     ||||:||::.|. .:..:..||:.:||||....|: .|.....|:.|.
pombe    83 YNNRKNQVRNPDFKYDEDCLFLNIWVPAGEKPAEGWPVLYFIHGGWLQVGNPLHYRQCDPQDLQA 147

  Fly   145 --DTNKVVMVTMNYRLGPFGFLSTGDEHM-----PGNFGFKDQRLALQWIQKHIATFGGDPKKVT 202
              ...|.::|:..:||..||||: |.|.:     ..||||.||||.|:|..|||.:|||:.:.:.
pombe   148 DGSPAKFILVSPGHRLNLFGFLA-GKELLEEDPKSSNFGFWDQRLGLEWTYKHIESFGGNKENIA 211

  Fly   203 VLGHSAGGISAHLHMI----SPNSKGLFQNSMSLTGTMFLSAMKILKDPL---SQARRLGKELAI 260
            |.|.|||..||...:|    .|.:..:.:.::.|:..:.:....:.:..:   ..|::.|..|.:
pombe   212 VGGISAGSYSALFQLIYETYHPEANQIIKRALLLSNGLSVQPKSVEESQIQFNELAQKFGIPLEL 276

  Fly   261 DQAESLSS------QDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPL 319
            ..||.|..      ||||:.:.|:.........|.                :..:|:.|  :|..
pombe   277 SSAEKLEKLRAIPFQDLADNILNLRLHTFRAVTDG----------------DFVNPNTF--KDIY 323

  Fly   320 DAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAE--FNE--NFLEHMALLLNLPEGTPV 380
            |.....||......|.:.....|.|::   |..||....|  ||:  |:.             |.
pombe   324 DGTFGKRIRDSGRELIIGEVNNEHSIY---ANTNPPKSKEDLFNQVNNYY-------------PE 372

  Fly   381 QMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYAN--------------L 431
            ::...:|:.|....|.  .|....||.|...|.      ..:|....||:              |
pombe   373 KVTKALLELYPKVPDM--EDEKEYLAAIKALFG------SIVSDMQVYASTRVLINGLVKGGVPL 429

  Fly   432 EENPLFIYIFEFAGLNSITKFF------------AGTTDDYGLGAVHMDDGLHTIRIPV------ 478
            |:  ::.|...|.|     |||            ||   |.||...::.||:....||:
pombe   430 EK--IYRYRIAFRG-----KFFDKYEPPESLVPHAG---DLGLWFYNVVDGILPEEIPIYKAWLK 484

  Fly   479 SFDDFPKDSEDAKVIQRMSSLMTDFAKT 506
            |:.::            ||:..||:..|
pombe   485 SYGEW------------MSTGKTDWGTT 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	137/544 (25%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	41/113 (36%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	139/548 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860