DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Tg

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	130/470 - (27%)
Similarity:	191/470 - (40%)	Gaps:	111/470 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FMGIPFAQPPVGPLRLKNP-VPNEPWEGVLDAGAAKDSCIQ---RSYFAKEWGLMGVEDCLYLNV 106
            |:|:|:|.||:...|.:.| |.|  |.|..||...:.||.|   |:....:..    ||||||||
  Rat  2229 FLGVPYAAPPLAENRFQAPEVLN--WTGSWDATKLRSSCWQPGTRTPTPPQIS----EDCLYLNV 2287

  Fly   107 YRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHM 171
            :.|:|...: ..|:|:.|......||...:......|.....:::||.|||||.|||||:|.:.:
  Rat  2288 FVPENLVSN-ASVLVFFHNTVEMEGSGGQLNIDGSILAAVGNLIVVTANYRLGVFGFLSSGSDEV 2351

  Fly   172 PGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMI--SPNSKGLFQNSMSLTG 234
            .||:|..||..||.|:|.||..|||||::||:.....|...|.:|::  .|....||:.::.:.|
  Rat  2352 AGNWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGG 2416

  Fly   235 TMFLSAMKILKD-PLSQARRLGKEL-----AIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVW 293
            :....|..|..| ...||..|.||:     ::.:..|...|..|..| |....|||........|
  Rat  2417 SALSPAAIISPDRAQQQAAALAKEVGCPNSSVQEVVSCFRQKPANIL-NEAQTKLLAVSGPFHYW 2480

  Fly   294 DNM---PHLTTLPV--LEAPSP---DAFL---VEDPLDAHRA----------GRINQMP------ 331
            ..:   .:|..||.  |:.|.|   |..:   .:|.| .:||          ||.|...
  Rat  2481 GPVVDGQYLRELPSRRLKRPLPVKVDLLIGGSQDDGL-INRAKAVKQFEESQGRTNSKTAFYQAL 2544

  Fly   332 ------------------WILSLS---------SRAGEGS---LFIMRAFINPK---LRAEFNEN 363
                              |..||.         |||.|.:   .||:...:|..   .|......
  Rat  2545 QNSLGGEDSDARILAAAIWYYSLEHSTDDYASFSRALENATRDYFIICPIVNMASLWARRTRGNV 2609

  Fly   364 FLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTY 428
            |:.|      :||                   |..:.::..||::  .:.|..|.|   |:|..|
  Rat  2610 FMYH------VPE-------------------SYGHGSLELLADV--QYAFGLPFY---SAYQGY 2644

  Fly   429 ANLEENPLFIYIFEF 443
            .::||..|.:.:.::
  Rat  2645 FSMEEQSLSLKVMQY 2659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	130/470 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	40/103 (39%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		130/470 (28%)
		COesterase	2198..2719	CDD:278561	130/470 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930