DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and Ces2a

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	165/520 - (31%)
Similarity:	252/520 - (48%)	Gaps:	67/520 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFA 90
            |.:||:.  :...:|| ...|:|||||:|||||||...|...|||.||.||.:....|:|....
  Rat    39 GQVRGSFVHVKDTKSG-IHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIM- 101

  Fly    91 KEWGLMGV-------------EDCLYLNVYRPKNRAE-DKLPVMVYIHGGGFFSGSAHPMASGPE 141
               .|.|:             |||||||:|.|.:..| ..|||||:|||||...|||  ..:...
  Rat   102 ---NLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSA--SMNDAS 161

  Fly   142 YLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGH 206
            .|..|.::|:|::.||||..||.||||::..||:|:.||..||:|:|::||.|||:..|||:.|.
  Rat   162 TLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGG 226

  Fly   207 SAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLS-QARRLGKELA-IDQAESLSSQ 269
            ||||.|...|::||.|||||.      |.:..|.:.:|.|.:| ::..:.|.:| :...|:..|:
  Rat   227 SAGGTSVSSHVVSPMSKGLFH------GAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSE 285

  Fly   270 DLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLP-VLEAPSPDAFLVEDPLDAHRAGRINQMPWI 333
            .|...||....:::|......|:         :| |::.    .||.:.|.:...:|..:.:|.|
  Rat   286 ALIRCLRAKSKQEILAINQVFKM---------IPGVVDG----KFLPKHPQELLASGDFHPVPSI 337

  Fly   334 LSLSS-RAGEG-SLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDS 396
            :.::: ..|.| .:|:....|..|:..|.....|:..|..:.||.    :.:..|::.|  .||:
  Rat   338 IGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKSTAAQMMLPP----ECIDLIMEEY--MGDT 396

  Fly   397 LNNDTML-KLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDY 460
            .|.:|:. :...:.|||.|..|..:.       |:.:.:...:|.:||..|.|..|    .....
  Rat   397 ENPETLQEQFRHMLGDFMFVIPALQV-------AHFQRSQAPVYFYEFQHLPSFIK----QVRPS 450

  Fly   461 GLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESI--CKVSDFKEQ 523
            .:.|.|.||.|......:....|....|:..:.:|:.....:||:||..:.|.:  ..|.|..||
  Rat   451 HVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQ 515

Fly 524 523
Rat 516 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	158/498 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/104 (48%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	165/520 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940