Protein Alignment Jhedup and Ces1a

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001013786.2
• Gene: Ces1a / 244595
• MGIID: 3648919
• Length: 563
• Species: Mus musculus
• Alignment Length: 603
• Identity: 171/603 - (28%)
• Similarity: 260/603 - (43%)
• Gaps: 150/603 - (24%)

  Fly     9 LLFVAVAVGDSLDVCLEDMG---------CMRGTLMPGYQSGEFEA-----FMGIPFAQPPVGPL 59
            |..:|:|   ||:.|:. :|         .::|.:|..|.|.|..|     |:|:|||:||:|||
Mouse     3 LFALALA---SLNTCMA-LGHLSSPPVVDTLQGKVMGKYISLEGSAQPVAVFLGVPFAKPPLGPL 63

  Fly    60 RLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV--------------------EDCLYL 104
            |...|.|.|.|..|.:..:....|.|         :.||                    ||||||
Mouse    64 RFAPPQPAETWSSVKNTTSYPPMCSQ---------ITGVGPVLSDVFTNQLENVPLEYSEDCLYL 119

  Fly   105 NVYRPKN-RAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNK-VVMVTMNYRLGPFGFLSTG 167
            |:|.|.: .::|:|||||::||||..||.|   ::.....:.|:: ||:|.:.||||.:||||||
Mouse   120 NIYSPTDLTSKDRLPVMVWVHGGGLLSGGA---STFDGLALSTHENVVIVVIQYRLGIWGFLSTG 181

  Fly   168 DEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMS- 231
            |||..||:|..||..||||:|.:||.|||||..||:.|.||||.|..:.::||.:|.|||.::|
Mouse   182 DEHSRGNWGHLDQVAALQWVQNNIANFGGDPSSVTLFGESAGGESVSVLVLSPLTKNLFQRAISE 246

  Fly   232 ----LTGTMFLSAMKILKDPLSQARRLGKELAI-DQAESLSSQDLAEALRNVCPKKLLVSVDSLK 291
                ||..:|...          .||..:::|| ....:.:|.|:...||....::||.:...:|
Mouse   247 SGVALTPCLFRET----------TRRAAEQVAIATGCVATTSADIVHCLREKTEEELLATTLKMK 301

  Fly   292 VW---------DNMPHLTTL--PVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSL 345
            .:         ::.|.|||:  .|:...:|:..|.|.        ..|.:|:|:.::.:  |...
Mouse   302 FFALDLLGDPRESYPFLTTVIDGVVLPKAPEEILAEK--------SFNTVPYIVGINKQ--EFGW 356

  Fly   346 FIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEIL------------DAYDFKGDSLN 398
            ||......|     .:|..|:..:....|.:..|:..:|:.|            |..|.|.|
Mouse   357 FIPMMMGYP-----LSEGKLDQKSATSLLWKSYPLTNISKELTPVATEKYLGGSDCPDKKKD--- 413

  Fly   399 NDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLG 463
                 ...::.||..|..|.. .::.|...|...     .|::||       |:......|....
Mouse   414 -----LFLDMMGDVLFAVPSV-IVARYHRDAGAP-----TYMYEF-------KYHPSFVSDMRPK 460

  Fly   464 AVHMDDGLHTIRI---PVSFDDFPKD---SEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKE 522
            .|..|.|.....:   |     |.|:   .|:..:...|.....:||:.|..:.|.:....::
Mouse   461 TVIADHGDEVYSVWGTP-----FLKEGASEEEINLSTMMMKFWGNFARNGNPNGEGLPHWPEY-- 518

  Fly   523 QGMCNYLHFGGNKEKYLE 540
                      |.||.||:
Mouse   519 ----------GEKESYLQ 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	157/538 (29%)
Ces1a	NP_001013786.2	COesterase	22..545	CDD:395084	164/580 (28%)