DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces1c

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	148/532 - (27%)
Similarity:	236/532 - (44%)	Gaps:	66/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RGTLMPGYQSGE-----FEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFA 90
            :|.::..|.|.|     ...|:|:|||:||:|.||...|.|.|||..|.:.......|.|.....
  Rat    32 KGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYPPMCSQDGVVG 96

  Fly    91 K------EWGLMGV-----EDCLYLNVYRPKNRAED-KLPVMVYIHGGGFFSGSAHPMASGPEYL 143
            |      ..|...:     |||||||:|.|.:..:: :|||||:|||||...|.|.|. ||....
  Rat    97 KLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGLIIGGASPY-SGLALS 160

  Fly   144 MDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSA 208
            ...| ||:||:.||||.:|..||||||..||:...||..||:|:|.:||.|||:|..||:.|.||
  Rat   161 AHEN-VVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESA 224

  Fly   209 GGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAE 273
            ||:|..:.::||.:|.||..::|.:|.:..:.:. .|:..:.|:.:.   .:....:.||..:.:
  Rat   225 GGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLD-KKNTQAVAQMIA---TLSGCNNTSSAAMVQ 285

  Fly   274 ALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAP-SPDAFLVEDPLDAHRAGRINQMPWILSLS 337
            .||.....:||.....|   ||....|.:..:..| :|:..|.|.        ..|.:|:|:..:
  Rat   286 CLRQKTEAELLELTVKL---DNTSMSTVIDGVVLPKTPEEILTEK--------SFNTVPYIVGFN 339

  Fly   338 SRAGEGSLFIMRAFINPKLRAEFNE----NFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLN 398
            .:  |....|.....|.......||    :.|...:..||:.|    .::..|::.| .:|
  Rat   340 KQ--EFGWIIPTMMGNLLSEGRMNEKMASSLLRRFSPNLNISE----SVIPAIIEKY-LRG---- 393

  Fly   399 NDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLG 463
            .|...|..|:..|  .:..::..|.:.:...:|.:.....|::||....|    |........:.
  Rat   394 TDDPAKKKELLLD--MFSDVFFGIPAVLMSRSLRDAGAPTYMYEFQYRPS----FVSDQRPQTVQ 452

  Fly   464 AVHMDDGLHTIRIPVSFDDFPKD---SEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGM 525
            ..|.|:.......|     |.|:   .|:..:.:.:.....:||:.|..:.|.:....::.::.
  Rat   453 GDHGDEIFSVFGTP-----FLKEGASEEETNLSKLVMKFWANFARNGNPNGEGLPHWPEYDQKE- 511

  Fly   526 CNYLHFGGNKEK 537
             .||..|...::
  Rat   512 -GYLQIGATTQQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	143/501 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/104 (50%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	148/532 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920