Protein Alignment Jhedup and CES3

DIOPT Version :9

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 173/573 - (30%)
• Similarity: 257/573 - (44%)
• Gaps: 89/573 - (15%)

  Fly     2 LFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGE------FEAFMGIPFAQPPVGPLR 60
            :..|...||....|.....:|...::....|.:. |.|.|.      ...|:||||||||:||.|
Human    11 VLVGVVCLLLACPATATGPEVAQPEVDTTLGRVR-GRQVGVKGTDRLVNVFLGIPFAQPPLGPDR 74

  Fly    61 LKNPVPNEPWEGVLDAGAAKDSCIQ--RSYFAKEWGLMG-------VEDCLYLNVYRPKN-RAED 115
            ...|.|.:|||||.||..|...|:|  .|..:..:.|.|       .||||.||||.|.. .|..
Human    75 FSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGS 139

  Fly   116 KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQ 180
            ..||||::|||...:|:|  .:.....|.....||:||:.||||..||.||||||.|||.||.|.
Human   140 GRPVMVWVHGGALITGAA--TSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDV 202

  Fly   181 RLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILK 245
            ..||:|:|::||.||||...|||.|.||||......::||.:.|||..:::.:|.:....: |..
Human   203 VAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGI-IDS 266

  Fly   246 DPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSP 310
            .|...|:::...||   ..|.|..::.:.|:....::|::   |.|:.:.:..||....:...||
Human   267 HPWPLAQKIANTLA---CSSSSPAEMVQCLQQKEGEELVL---SKKLKNTIYPLTVDGTVFPKSP 325

  Fly   311 DAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLP 375
            ...|.|.|        .:.:|:::.:::.  |.|..|.|.:   .|.....:...|.| |.::.|
Human   326 KELLKEKP--------FHSVPFLMGVNNH--EFSWLIPRGW---GLLDTMEQMSREDM-LAISTP 376

  Fly   376 EGT----PVQMVSEILDAYDFKGDSLNNDTMLK---LAEISGDFNFYYPIYETISSYVTYANLEE 433
            ..|    |.:|:..::|.|  .|.  |:|...|   ..|..||.....|   |: |:..|.....
Human   377 VLTSLDVPPEMMPTVIDEY--LGS--NSDAQAKCQAFQEFMGDVFINVP---TV-SFSRYLRDSG 433

  Fly   434 NPLFIYIFE-----FAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDD-----FPKDSE 488
            :|:|.|.|:     ||.:..     |....|:|.      :|......|...|:     ||:.:|
Human   434 SPVFFYEFQHRPSSFAKIKP-----AWVKADHGA------EGAFVFGGPFLMDESSRLAFPEATE 487

  Fly   489 DAKVIQ-RMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLE 540
            :.|.:. .|.:..|.||:||..:.:::.....|.:            .|:|||
Human   488 EEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQ------------AEQYLE 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	162/510 (32%)
		Aes	<106..>210	CDD:223730	52/104 (50%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	168/552 (30%)
		Aes	<129..>247	CDD:223730	56/119 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840