DRSC/TRiP Functional Genomics Resources

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Protein Alignment Jhedup and CES3

DIOPT Version :10

Sequence 1:NP_611085.2 Gene:Jhedup / 36779 FlyBaseID:FBgn0034076 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_079198.2 Gene:CES3 / 23491 HGNCID:1865 Length:571 Species:Homo sapiens


Alignment Length:573 Identity:173/573 - (30%)
Similarity:257/573 - (44%) Gaps:89/573 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LFAGFGVLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGE------FEAFMGIPFAQPPVGPLR 60
            :..|...||....|.....:|...::....|.:. |.|.|.      ...|:||||||||:||.|
Human    11 VLVGVVCLLLACPATATGPEVAQPEVDTTLGRVR-GRQVGVKGTDRLVNVFLGIPFAQPPLGPDR 74

  Fly    61 LKNPVPNEPWEGVLDAGAAKDSCIQ--RSYFAKEWGLMG-------VEDCLYLNVYRPKN-RAED 115
            ...|.|.:|||||.||..|...|:|  .|..:..:.|.|       .||||.||||.|.. .|..
Human    75 FSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGS 139

  Fly   116 KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQ 180
            ..||||::|||...:|:|  .:.....|.....||:||:.||||..||.||||||.|||.||.|.
Human   140 GRPVMVWVHGGALITGAA--TSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDV 202

  Fly   181 RLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILK 245
            ..||:|:|::||.||||...|||.|.||||......::||.:.|||..:::.:|.:....: |..
Human   203 VAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGI-IDS 266

  Fly   246 DPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSP 310
            .|...|:::...||   ..|.|..::.:.|:....::|::   |.|:.:.:..||....:...||
Human   267 HPWPLAQKIANTLA---CSSSSPAEMVQCLQQKEGEELVL---SKKLKNTIYPLTVDGTVFPKSP 325

  Fly   311 DAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLP 375
            ...|.|.|        .:.:|:::.:::.  |.|..|.|.:   .|.....:...|.| |.::.|
Human   326 KELLKEKP--------FHSVPFLMGVNNH--EFSWLIPRGW---GLLDTMEQMSREDM-LAISTP 376

  Fly   376 EGT----PVQMVSEILDAYDFKGDSLNNDTMLK---LAEISGDFNFYYPIYETISSYVTYANLEE 433
            ..|    |.:|:..::|.|  .|.  |:|...|   ..|..||.....|   |: |:..|.....
Human   377 VLTSLDVPPEMMPTVIDEY--LGS--NSDAQAKCQAFQEFMGDVFINVP---TV-SFSRYLRDSG 433

  Fly   434 NPLFIYIFE-----FAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDD-----FPKDSE 488
            :|:|.|.|:     ||.:..     |....|:|.      :|......|...|:     ||:.:|
Human   434 SPVFFYEFQHRPSSFAKIKP-----AWVKADHGA------EGAFVFGGPFLMDESSRLAFPEATE 487

  Fly   489 DAKVIQ-RMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLE 540
            :.|.:. .|.:..|.||:||..:.:::.....|.:            .|:|||
Human   488 EEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQ------------AEQYLE 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JhedupNP_611085.2 alpha/beta hydrolases 31..508 CDD:473884 162/510 (32%)
CES3NP_079198.2 COesterase 32..547 CDD:395084 168/552 (30%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.

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