DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces2b

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	567	Identity:	173/567 - (30%)
Similarity:	250/567 - (44%)	Gaps:	117/567 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FGVLLFVAVAVG----DSLDVCLEDMGCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNP 64
            ||:||.:....|    ::..:.....|.:||:|  :...::| ...|:|||||:|||||||...|
Mouse    15 FGLLLLLGHVQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAG-VHTFLGIPFAKPPVGPLRFAPP 78

  Fly    65 VPNEPWEGVLDAGAAKDSCIQRSYFAKEWGL-----MGVEDCLYLNVYRPKNRAE-DKLPVMVYI 123
            ...|||.||.|..|....|:|.....||..|     ...|||||||:|.|.:..| ..|||||:|
Mouse    79 EAPEPWSGVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLPVMVWI 143

  Fly   124 HGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQ 188
            ||||..:|.| .|..| ..|.....:|:||:.||||..||.||||:|..||:||.||..||:|||
Mouse   144 HGGGLVAGMA-SMYDG-SLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGFLDQVAALRWIQ 206

  Fly   189 KHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMS----------LTGTMFLSAMKI 243
            ::||.|||.|.:||:.|.||||.|...|::||.|||||..::.          :|.|..:.:..:
Mouse   207 QNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTSEMVSTTV 271

  Fly   244 LKDPLSQARRLGKELAI------DQAESLSSQDLAEALRNVC--------PKKLLVSVDSLKVWD 294
            .|  ||....:..|..:      .:||.|:...|.:.:..|.        ||:||.|.|.
Mouse   272 AK--LSGCEAMDSEALVRCLRGKSEAEILAINKLVQMIPAVVDGEFFPRHPKELLASEDF----- 329

  Fly   295 NMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAE 359
               |         |.|....|.:          ::..|.:.:..    ||...::......|:|.
Mouse   330 ---H---------PVPSIIGVNN----------DEFGWTIPVVM----GSAQTIKEITRENLQAV 368

  Fly   360 FNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTM-LKLAEISGDFNFYYPIYETIS 423
            ....    .|.|:..||.:.:.|       .::.||:.:..|: ::..|:..||.|..|..:.
Mouse   369 LKNT----TAQLMLPPECSDLLM-------EEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQV-- 420

  Fly   424 SYVTYANLEENPLFIYIFEF----AGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFP 484
                 |..:.:...:|.:||    |.|..:....        :.|.|.|:      ||..|..|.
Mouse   421 -----AYFQRSHASVYFYEFQHQIASLKDVRPTH--------VKADHADE------IPFVFGYFF 466

  Fly   485 KD-----SEDAKVI-QRMSSLMTDFAKTGVFHEESI--CKVSDFKEQ 523
            .|     :|..|:: :||.....:||:.|..:.|.:  ..|.|..||
Mouse   467 WDMKLDFTEGEKLLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	161/519 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	54/104 (52%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	168/548 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840