Protein Alignment Jhedup and Aadacl3

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001078972.1
• Gene: Aadacl3 / 230883
• MGIID: 2685281
• Length: 408
• Species: Mus musculus
• Alignment Length: 416
• Identity: 90/416 - (21%)
• Similarity: 134/416 - (32%)
• Gaps: 123/416 - (29%)

  Fly   104 LNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGD 168
            :.:|:||..:......:::.||||...||.....|....|......|:|::.||..|.
Mouse   100 VKLYKPKKPSSIPRLGIIFFHGGGTIIGSLRTHNSICLRLSKECDSVVVSVGYRKSPM------- 157

  Fly   169 EHMPGNFGFK------DQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQ 227
                    :|      |..:|.....:.:..:|.||.:|...|.|.||.:|.:
Mouse   158 --------YKYPVMKDDCVVATTHFLESLDVYGVDPARVVTCGDSVGGTAATV------------ 202

  Fly   228 NSMSLTGTMFLSAMK--ILKDPLSQARRLGKELAIDQAES--LSSQDLAEALRNVCPKKLLVSVD 288
            .|..|.....|..:|  ||..||.|....|.. :..|..:  |.|.||  |....| ..|.|::.
Mouse   203 TSQMLVHRPDLPRIKAQILIYPLLQLIDFGSP-SYQQNRNIPLLSWDL--AFYCFC-CHLDVNIS 263

  Fly   289 SLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFIN 353
            ...|..|..||         .||.:      :.:|       .|:         |:..|...|.|
Mouse   264 WKSVVKNGMHL---------PPDVW------EKYR-------KWL---------GAENIPERFKN 297

  Fly   354 PKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPI 418
            ...:               ::|.| ||                 |||.   ..||....|  |..
Mouse   298 RGYK---------------SIPWG-PV-----------------NNDA---YQEIKRSLN--YTC 324

  Fly   419 YETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAV--HMDDGLHTIRIPVSFD 481
            ...||.....:.|.|.  .|...|:..|...:..:....:|.|:...  ||:||.|.:...:.:.
Mouse   325 SPLISEDSIVSQLPET--CIVSCEYDLLRDHSLLYKKRLEDLGVPVTWHHMEDGFHGVLSALDYG 387

  Fly   482 --DFPKDSEDAKVIQRMSSLMTDFAK 505
              .||..|       |:..|:..|.:
Mouse   388 LLSFPCAS-------RIMDLIIQFIR 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	90/416 (22%)
Aadacl3	NP_001078972.1	Abhydrolase_3	116..379	CDD:400284	80/364 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	120..122		1/1 (100%)