DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and NLGN1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	693	Identity:	181/693 - (26%)
Similarity:	270/693 - (38%)	Gaps:	195/693 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GVLLFVAVAVGDSLD----VCLEDMGCMRG--------TLMPGYQSGEFEAFMGIPFAQPPVGPL 59
            |.||.....:...||    :...:.|.:||        .|.|..|      |:|:|:|.||.|..
Human    35 GCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQ------FLGVPYAAPPTGER 93

  Fly    60 RLKNPVPNEPWEGVLDAGAAKDSCIQR-----------------------SYFAKEWGLMGVEDC 101
            |.:.|.|..||..:.:|......|.|.                       ||...:     .|||
Human    94 RFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQ-----SEDC 153

  Fly   102 LYLNVYRP----------------KNRAEDK--------LPVMVYIHGGGFFSGSAHPMASGPEY 142
            ||||:|.|                .:.|||:        .|||||||||.:..|:.: :..| ..
Human   154 LYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGN-LYDG-SV 216

  Fly   143 LMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHS 207
            |.....|:::|:|||||..|||||||:...||:|..|...||:|..::|..|||||.::||.|..
Human   217 LASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSG 281

  Fly   208 AGGISAHLHMI---------SPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQA 263
            |||...:|..:         |.::|||||.:::.:||. ||:..:...|...||.|..::..:.:
Human   282 AGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTA-LSSWAVSFQPAKYARMLATKVGCNVS 345

  Fly   264 ESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRIN 328
            :::   :|.|.|:.. |.|.||..|   :.....|:...||::..    .:.:||......|..
Human   346 DTV---ELVECLQKK-PYKELVDQD---IQPARYHIAFGPVIDGD----VIPDDPQILMEQGEF- 398

  Fly   329 QMPWILSLSSRAGEGSLFIMRAFINPK--LRAEFN---ENFLEHMALLLNLPEGTPVQMVSEILD 388
             :.:.:.|....|||..|:.....:..  ..::|:   .||:::   |...|||..| :...|..
Human   399 -LNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDN---LYGYPEGKDV-LRETIKF 458

  Fly   389 AYDFKGDSLNNDTMLK-LAEISGDFNFYYPIYETISSYVTYANLEEN---PLFIYIFEFAGLNSI 449
            .|....|..|.:|..| |..:..|..:..|...|       |:|..|   |.:.|.|
Human   459 MYTDWADRHNPETRRKTLLALFTDHQWVAPAVAT-------ADLHSNFGSPTYFYAF-------- 508

  Fly   450 TKFFAGTTDDY--GLGAVHMDDGLHTIRIPV--SFDDFPKD--SEDAKVIQRMSSLMTDFAKTG- 507
              :....||..  ...|.|.|:..:.:.||:  ..:.||.:  ..|..:...:.:..|:|||||
Human   509 --YHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGD 571

  Fly   508 -----------------VFHEESICKVSDFKEQGMCNYLHFGGN---KEKY-------------- 538
                             .|.|.:..:.|. |:|   .|||.|..   ||.|
Human   572 PNQPVPQDTKFIHTKPNRFEEVAWTRYSQ-KDQ---LYLHIGLKPRVKEHYRANKVNLWLELVPH 632

  Fly   539 ---LEDI---------------------RNSITLT-AFPIWKK 556
               |.||                     :||:.:| |||..|:
Human   633 LHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQ 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	153/573 (27%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	48/127 (38%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	166/624 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740