Protein Alignment Jhedup and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 168/641 - (26%)
• Similarity: 259/641 - (40%)
• Gaps: 143/641 - (22%)

  Fly     8 VLLFV-AVAVGDSL-------DVCLEDMGCMRG--TLMPGYQSGEFEAFMGIPFAQPPVGPLRLK 62
            |||:: |:|:..:|       .|...:.|.::|  |.:|....|..|.::|:|:|.||.|..|.:
Human    25 VLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQ 89

  Fly    63 NPVPNEPWEGVLDAGAAKDSCIQR------------SYFAKEWGLMGV------EDCLYLNVYRP 109
            .|.....|.|:.:|......|.|.            .:|......:..      |||||||:|.|
Human    90 PPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVP 154

  Fly   110 -------KNRAED-----------------KLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVV 150
                   |..|:|                 |.|||||||||.:..|:.: |..| ..|.....|:
Human   155 MEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGN-MIDG-SILASYGNVI 217

  Fly   151 MVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHL 215
            ::|:|||||..|||||||:...||:|..||..||:||::::..||||||:||:.|..||.....|
Human   218 VITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSL 282

  Fly   216 HMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLAEALRNVCP 280
            ..:|..|:||||.::..:||. ||:..:...|....|.|..::..:.   |.:.|:.|.|:|...
Human   283 LTLSHYSEGLFQKAIIQSGTA-LSSWAVNYQPAKYTRILADKVGCNM---LDTTDMVECLKNKNY 343

  Fly   281 KKLLVSVDSLKVWDNMPHLTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSL 345
            |:|:....:...:    |:...||::..    .:.:||......|..  :.:.:.|....|||..
Human   344 KELIQQTITPATY----HIAFGPVIDGD----VIPDDPQILMEQGEF--LNYDIMLGVNQGEGLK 398

  Fly   346 FI-----MRAFINPKLRAEFN---ENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTM 402
            |:     ....:.|.   :|:   .||:::   |...|||... :...|...|....|..|.:|.
Human   399 FVDGIVDNEDGVTPN---DFDFSVSNFVDN---LYGYPEGKDT-LRETIKFMYTDWADKENPETR 456

  Fly   403 LK-LAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVH 466
            .| |..:..|..:..|...|...:..|.    :|.:.|.|.....:.:...:|
Human   457 RKTLVALFTDHQWVAPAVATADLHAQYG----SPTYFYAFYHHCQSEMKPSWA------------ 505

  Fly   467 MDDGLHTIRIPVSFD------------DFPKDSEDAKVIQRMSSLMTDFAKTG------------ 507
              |..|...:|..|.            :|.|:  |..:...:.:..|:|||||
Human   506 --DSAHGDEVPYVFGIPMIGPTELFSCNFSKN--DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF 566

  Fly   508 ------VFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITLTAFPIWKKL 557
                  .|.|.:..|.:. |:|   .|||.|....     :|:....|....|.:|
Human   567 IHTKPNRFEEVAWSKYNP-KDQ---LYLHIGLKPR-----VRDHYRATKVAFWLEL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	147/559 (26%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	160/617 (26%)