DRSC/TRiP Functional Genomics Resources

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Protein Alignment Jhedup and Nlgn2

DIOPT Version :9

Sequence 1:NP_611085.2 Gene:Jhedup / 36779 FlyBaseID:FBgn0034076 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001351066.1 Gene:Nlgn2 / 216856 MGIID:2681835 Length:836 Species:Mus musculus


Alignment Length:606 Identity:162/606 - (26%)
Similarity:252/606 - (41%) Gaps:154/606 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 GEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGV------- 98
            |....|:|:|:|.||:|..|.:.|.....|.||.:|.....:|.|..:.|....::.|       
Mouse    64 GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLE 128

  Fly    99 ----------EDCLYLNVYRP-------KNRAE-------------DKLPVMVYIHGGGFFSGSA 133
                      |||||||:|.|       |.|.|             .|.|||:::|||.:..|:.
Mouse   129 AAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTG 193

  Fly   134 HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDP 198
            : |..| ..|.....|::||:|||||..|||||||:...||:|..||..||:|:.::||.|||||
Mouse   194 N-MFDG-SVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDP 256

  Fly   199 KKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQA 263
            :::|:.|..||....:|.::|.:|:||||.:::.:||. :|:..:...||...|.|..::..|:.
Mouse   257 ERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA-ISSWSVNYQPLKYTRLLAAKVGCDRE 320

  Fly   264 ESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMP---HLTTLPVLEAP-SPDAFLVEDPLDAHRA 324
            :   |.:..|.||....::|   ||.    |..|   |:...||::.. .||     ||....:.
Mouse   321 D---STEAVECLRRKSSREL---VDQ----DVQPARYHIAFGPVVDGDVVPD-----DPEILMQQ 370

  Fly   325 GRINQMPWILSLSSRAGEGSLFI-----------MRAFINPKLRAEFN-ENFLEHMALLLNLPEG 377
            |.......::.::.  |||..|:           ..||       :|. .||:::   |...|||
Mouse   371 GEFLNYDMLIGVNQ--GEGLKFVEDSAESEDGVSASAF-------DFTVSNFVDN---LYGYPEG 423

  Fly   378 TPVQMVSEIL-----DAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLF 437
            ..|  :.|.:     |..|.....:...|:|.|..   |..:..|...|...:..|    ::|::
Mouse   424 KDV--LRETIKFMYTDWADRDNGEMRRKTLLALFT---DHQWVAPAVATAKLHADY----QSPVY 479

  Fly   438 IYIF----------EFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPV--SFDDFPKD--SE 488
            .|.|          |:|                  .|.|.|:..:...:|:  :.|.||.:  ..
Mouse   480 FYTFYHHCQAEGRPEWA------------------DAAHGDELPYVFGVPMVGATDLFPCNFSKN 526

  Fly   489 DAKVIQRMSSLMTDFAKTG-----------VFH------EESICKVSDFKEQGMCNYLHFGGNKE 536
            |..:...:.:..|:|||||           ..|      ||.:....:.||:   .|||.|....
Mouse   527 DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEK---QYLHIGLKPR 588

  Fly   537 KYLEDIRNSITLTAFPIWKKL 557
                 :|::........|.:|
Mouse   589 -----VRDNYRANKVAFWLEL 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JhedupNP_611085.2 COesterase 31..508 CDD:278561 150/549 (27%)
Aes <106..>210 CDD:223730 49/123 (40%)
Nlgn2NP_001351066.1 COesterase 42..601 CDD:306613 160/601 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..661
Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354 679..699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 791..836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832821
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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