DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces2e

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	166/554 - (29%)
Similarity:	254/554 - (45%)	Gaps:	115/554 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDSLD-VCLEDMGCMRGTL--MPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEP 69
            :|||..|...||.. :.....|.:||:.  :...:|| ...|:|||||:||:||||...|.|.||
  Rat    18 LLLFCQVQGQDSASPIRNTHTGQVRGSFVHVKDTKSG-VHTFLGIPFAKPPIGPLRFAPPEPPEP 81

  Fly    70 WEGVLDAGAAKDSCIQ---------------RSYFAKEWGLMGVEDCLYLNVYRPKNRAED-KLP 118
            |.||.|..:....|:|               ||..:..      ||||||::|.|.:..:| .||
  Rat    82 WSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSMS------EDCLYLSIYTPAHTHKDSNLP 140

  Fly   119 VMVYIHGGGFFSGSAHPMAS--GPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQR 181
            |||:|||||...|    |||  ....|.....||:||:.||||..||.||||||..||:|:.||.
  Rat   141 VMVWIHGGGLCWG----MASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGNWGYLDQV 201

  Fly   182 LALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKD 246
            .||:|:|::|..|||:|.:||:.|.||||||...|::||.|:|||.      |.:..|.:.:|.:
  Rat   202 AALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFH------GAIMESGVALLPN 260

  Fly   247 PLSQARRLGKELA--IDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPS 309
            .:|....:...:.  :...|.:.|:.|...||....:::|...:.::        |...|::.
  Rat   261 LISNTSEVIYTMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVR--------TISGVVDG-- 315

  Fly   310 PDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLR-----AEFNENFLEHMA 369
              .||...||:...:...:.:|.|:.::|..        ..:|.|.|.     .|.|...:.  |
  Rat   316 --KFLPRHPLELLASVDFHPVPSIIGINSDE--------YGWIIPMLHPDSTMKEINRETMR--A 368

  Fly   370 LLLNLPEGTPVQMV-----SEILDAYDFKGDSLNNDTM-LKLAEISGDFNFYYPIYETISSYVTY 428
            :|.|    |.|||:     |::| ..::.||:.::.|: ::..|:.|||.|..|..:.
  Rat   369 VLKN----TAVQMMLPPECSDLL-MEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQV------- 421

  Fly   429 ANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFP--------- 484
            |:.:.:...:|.:||...::..|       |.....|..|.|          |:.|
  Rat   422 AHFQRSHAPVYFYEFQHQSNFLK-------DIRPPHVKADHG----------DELPYVIGYLFWD 469

  Fly   485 ---KDSEDAKVIQR-MSSLMTDFAKTGVFHEESI 514
               ..:|:.|::.| |.....:||:.|..:.|.:
  Rat   470 MKFVFTEEEKLLSRKMIKYWANFARHGNPNSEGL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	157/522 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	53/106 (50%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	160/542 (30%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	53/106 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840