DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and cest-28

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	152/584 - (26%)
Similarity:	235/584 - (40%)	Gaps:	142/584 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRGTLMPGYQSGE--FEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFA 90
            |.::|.:   |:.|:  .:.::|||||:|.|   |.|.|.|...||.|.|.......|.|...||
Worm    22 GPIQGNV---YRIGDKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRCPQSGPFA 80

  Fly    91 KEWGLMGVE-----DCLYLNVYR----PKNRAEDKLPVMVYIHGGGFFSGSAHP----MASGPEY 142
            :.......:     :||.|||:.    .||..:.: ||||||||||:...::..    ..:|...
Worm    81 EAINFQKDDIPDEANCLTLNVFSKISDSKNFNKTR-PVMVYIHGGGYECSASRDYCDYSVAGTLP 144

  Fly   143 LMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHS 207
            |.|   ||:||:|||:|..||.:|||...||||...|..|.|.||||||.:|||||..:|:.|.|
Worm   145 LKD---VVVVTLNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFGQS 206

  Fly   208 AGGISAHLHMISPNSKGLFQNSMSLTGTMFLS-AMKILKDPLSQARRLGKELAIDQAESLSSQDL 271
            ||.....|..:||:|:.||...:.::|..... |::.............:.|..|...|
Worm   207 AGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFARHLGYDGTNS------ 265

  Fly   272 AEALRNVCPKKLLVSVDSLK----------VW------DNMPHLTTLPVLEAPSPD--------- 311
             :.|.|....|.|..::.:.          .|      |..|.......:.||..|
Worm   266 -QTLFNWMKSKPLEEIEKMNGFQVPASGILAWTPNLDDDFFPKSLDELRIGAPKKDIMMGFAEHE 329

  Fly   312 ----AFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLL 372
                .||::||.....|                       ::.::|...:.:..::|
Worm   330 GLFFEFLIKDPTPPLEA-----------------------LKLYVNEYYKKDTGDHF-------- 363

  Fly   373 NLPEGTPVQMVSEILDAYDFK-GDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPL 436
               |.|.    ::|::.|... .|:....|..:|.:..||..|...:::...:.:.:.    |.:
Worm   364 ---EATR----NKIIEFYSRNVEDTDEKSTKERLIDFVGDALFTAGVFDNAKNCLKHG----NNV 417

  Fly   437 FIYIFE------FAGLNSITKFFAGT--TD-DYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKV 492
            ::|||:      |........|.|.|  || .|.||     :||        :.||....|:.|:
Worm   418 WLYIFDYCNPSGFGNQEEFMTFVAPTHCTDLRYVLG-----EGL--------YSDFQPTEEEHKM 469

  Fly   493 IQRMSSLMTDFAKTGVFHEESICKVSDFKEQG-------------MCNYLHFGGNKEKYLEDIR 543
            |::|:::.::|||.|..:|....:...|....             |.|..|  .::.|:||.||
Worm   470 IEKMTTIYSNFAKYGNPNEHGSSEWEKFTLDNPRRHFQISYPRGKMRNDYH--PDRMKFLELIR 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	140/531 (26%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	51/111 (46%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	144/565 (25%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	52/113 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820