DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and cest-19

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	152/536 - (28%)
Similarity:	233/536 - (43%)	Gaps:	115/536 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GCMRG-TLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEP--WEGVLDAGAAKDSCIQ---- 85
            |.:|| .|:...|  ::..|.|||||.||||.||.:  :|.||  |.||::|......|:|
Worm    33 GAIRGERLLTDGQ--DYSVFKGIPFAMPPVGYLRFQ--MPKEPAKWRGVMNATQYSAMCMQNIDE 93

  Fly    86 ------RSYFAKEWGLMGVEDCLYLNVYRPK--NRAEDKLPVMVYIHGGGFFSGSAHPMASGPEY 142
                  ..|.|..     .||||||||:.|.  ....|..||:|:||||.|.:||...:   |:.
Worm    94 NDAGEPERYVAHV-----SEDCLYLNVFSPTPYQYTNDTYPVIVFIHGGRFQTGSGSDI---PQR 150

  Fly   143 LMDTN----KVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTV 203
            .:.:|    |:|.||.||||||.||.||||..:|||.|..||..||:|::.:...|||||..:.:
Worm   151 AILSNFVSRKIVFVTFNYRLGPLGFASTGDSVLPGNIGLWDQIWALKWVKANAEVFGGDPSNILL 215

  Fly   204 LGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMF---------LSAMKILKDPLSQARRLGKELA 259
            :||..|..||.|..:||.::||||..:.::|:..         ::|...:.|... .|.......
Worm   216 MGHGTGAASASLLALSPRAEGLFQKVLLMSGSALQPGVVRNTQVNATWNMNDRFG-CRAFNSSEL 279

  Fly   260 IDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEA-----PSPDAFLVEDPL 319
            :|.|...|.:::.:..|        :..|..:.:        :|:::.     |.|     .:.|
Worm   280 LDCARKRSKEEIFQYKR--------LHFDDYEEF--------VPIIDGVGGILPEP-----PEQL 323

  Fly   320 DAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPK------LRAEFNENFLEHMALLLN----- 373
            ..||    .:.|.::..:.  .|.||.|:  .:|.|      :..|..|...:::.|...
Worm   324 TLHR----RKTPIVIGTTK--DESSLRIL--LLNEKDLNFSSITWENGETLADNLTLGFKQFQNH 380

  Fly   374 --LPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPL 436
              :.:|...:.|...:|. .|....|.| ::||:..     :|:|.  ...|...||....:.|:
Worm   381 RLISQGCKSEYVWTQVDP-SFPESVLFN-SLLKMYS-----HFWYD--APASQLATYYLKHDLPV 436

  Fly   437 FIYIFEFAGLN--SITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSE---DAKVIQRM 496
            ::|.|:....|  .|.:.|.|.            |.||...:...|.:..||..   |.:|::..
Worm   437 YLYSFDHISENFYDIDRAFHGV------------DKLHIFNVTPRFLNKRKDMNWQLDQRVVEIF 489

  Fly   497 SSLMTDFAKTGV-FHE 511
            |.|:.:||..|. .||
Worm   490 SELVANFALYGTPTHE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	148/527 (28%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	47/109 (43%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	152/536 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910