Protein Alignment Jhedup and cest-2.1

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_506508.2
• Gene: cest-2.1 / 179916
• WormBaseID: WBGene00013875
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 141/568 - (24%)
• Similarity: 242/568 - (42%)
• Gaps: 89/568 - (15%)

  Fly     9 LLFVAVAVGDSLDVCLEDMGCMRGTLMP-GYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEG 72
            ||.::::....|.....:...:..|..| |..:|  ..|:||||.:||.|.||.:.|.|..||:|
 Worm    12 LLHISISTRVQLSTGTIEGKILTSTYSPLGNHTG--IGFLGIPFVEPPAGNLRFRKPRPPIPWDG 74

  Fly    73 VLDAGAAKDSCIQRSYFAKEWGLMG--VEDCLYLNVY------RPKNRAEDKLPVMVYIHGGGFF 129
            :|:....|.:|:..:....:.|:.|  .|||||.||:      :.||     ..||:.:|||...
 Worm    75 ILETKEYKPACMSDAKKTYKNGVGGPISEDCLYANVFTNQYCMKRKN-----CSVMIVVHGGRIL 134

  Fly   130 SGSAHPMASGPEYLMDT-----NKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQK 189
            :.||  .|..||.|::.     ..:|:||.|||||.|||.....|....|.|..|...|::|.:|
 Worm   135 TESA--SAFNPEILVNNFVGQGRNIVVVTFNYRLGTFGFGVLNGEKGDSNVGMFDMLEAVKWTRK 197

  Fly   190 HIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMF-LSAMKILKDPLSQARR 253
            .:..|||:..|:|::||||||........||.|||:....:.::|.:: :..:...|...:.|::
 Worm   198 EVHNFGGNKDKLTMVGHSAGGSLVGAFTSSPLSKGMLNQQIIMSGALYQMGKLANFKGMTAMAQK 262

  Fly   254 LG-----------KELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEA 307
            .|           .::.||:..|        .|||:..:::|.:  .|.|..|..:..::|.::.
 Worm   263 AGCLPEVFGFRKLSQVRIDKTYS--------CLRNISAQEVLDA--QLWVLQNTTYYISVPHIDG 317

  Fly   308 PSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMAL-L 371
                .||:....:...:|.|:.:..::..::......::| ....|...:.|..:|..||:.. |
 Worm   318 ----EFLLNYSDEILASGTIHPINSMIGTTTAELRDPIYI-NDLKNADKKEELLKNLCEHIGYEL 377

  Fly   372 LNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPL 436
            ...||....:       ...|.|   |.|....||:   |..||....:..:::.:    :...:
 Worm   378 YTEPEEFSRK-------CQKFYG---NGDDAQFLAD---DMEFYDGSIKVANAHAS----KNTKV 425

  Fly   437 FIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMT 501
            |:|.:::.......|.:|.....:     |.:|.::.  ...|..:|.:  :|..:.|..|.:..
 Worm   426 FMYSYDYKDAGPAFKKYAQAPPPH-----HSEDLIYV--FGTSRGNFTE--KDYVIEQIYSGMFA 481

  Fly   502 DFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKY-LEDIRNSITL 548
            ||...|        ..|..|||   .:..:...|.:| |.|...:.|:
 Worm   482 DFVNFG--------NPSPSKEQ---KWKEYSPEKREYFLIDFDKNFTM 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	128/503 (25%)
cest-2.1	NP_506508.2	COesterase	18..533	CDD:395084	139/562 (25%)