Protein Alignment Jhedup and cest-1.2

DIOPT Version :10

• Sequence 1: NP_611085.2
• Gene: Jhedup / 36779
• FlyBaseID: FBgn0034076
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 157/600 - (26%)
• Similarity: 252/600 - (42%)
• Gaps: 110/600 - (18%)

  Fly     1 MLFAGFGVLLFVAVAVGDSLDVCLEDMGCMRG-----TLMP-GYQSGEFEAFMGIPFAQPPVGPL 59
            |:|. |.|||:.:.....|..|.| ..|.:.|     |..| |.||.  .||:|||:.:||:|.|
 Worm     1 MIFK-FVVLLWFSAQFAISTKVQL-STGIIEGKQLNSTYSPFGNQSA--IAFLGIPYVEPPIGDL 61

  Fly    60 RLKNPVPNEPWEGVLDAGAAKDSCIQRS---YFAKEWGLMG--VEDCLYLNVYRPKNRAEDK-LP 118
            |.:.|.|.:.|.|||:....|.:|:..|   |  |..|:.|  .||||||||...:...|:| ..
 Worm    62 RFRKPRPQKTWSGVLETKKFKPACMSNSTKTY--KNGGIGGPISEDCLYLNVLTNQYCLENKNCS 124

  Fly   119 VMVYIHGGGFFSGSA----HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPG-----N 174
            |::.:||||:...||    |.:........|.| :|:||:|||||.|||     .|:.|     |
 Worm   125 VVIIVHGGGYLFESAATFNHEILVNNFVGQDRN-IVVVTINYRLGIFGF-----GHLNGFEGDKN 183

  Fly   175 FGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMF-L 238
            .|..|...|::|:::.|..|||:..::|:.|||||........|||.:|||....:.::|.|. :
 Worm   184 VGIFDTLEAVKWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNM 248

  Fly   239 SAMKILKDPLSQARRLG---KELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVW--DNMPH 298
            |.....|...:.|.|:|   |:...::......:.:...||....::||    ..::|  .|...
 Worm   249 SKKSNFKGMTAMAERVGCHSKKYGFNKLPEHEVEQVYSCLRKKPAQELL----DAQLWLLQNSTF 309

  Fly   299 LTTLPVLEAPSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNEN 363
            ....|    |....|:.:.|.:.:....|..:..:|..::|..:.:.:|..:..:   :.|..|.
 Worm   310 YFGAP----PVDGEFITDYPDNLYSEKSIFSINTLLGTTTRELQDTGYISNSNYS---KFETKET 367

  Fly   364 FLEHMALLLNLPEGTPVQMVSEILDAYDFKGDS----LNNDTMLKLAEISGDFNFYYPIYETISS 424
            ||:      ||.:...:::..|   :.||....    :|......|   |.|..||........:
 Worm   368 FLK------NLCDQIGIEIYKE---SEDFSSKCQKWYINGSDSKSL---SDDMEFYTQAINLADA 420

  Fly   425 YVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDF-----P 484
            :..    :...:::|.:.::|.....|.:......:     |.:|.::|      |...     |
 Worm   421 HAR----KGKKVYMYSYAYSGAGPAFKKYMKVKSPH-----HSEDLIYT------FGTHRGVFAP 470

  Fly   485 KDSEDAKVIQRM-SSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSITL 548
            ||    .||:.: |.:..||..   |.:.     |...:|....|..  .|||.:|.|...::|:
 Worm   471 KD----YVIEYIYSGMFADFIN---FEDP-----SPSTDQPWLQYTK--ENKEYFLVDFDQNLTM 521

  Fly   549 ---------TAFPIW 554
                     .|:..|
 Worm   522 PGMKKNYYAKAYEFW 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	alpha/beta hydrolases	31..508	CDD:473884	135/513 (26%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	150/580 (26%)