DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jhedup and cest-5.1

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_501022.3	Gene:	cest-5.1 / 177429	WormBaseID:	WBGene00015279	Length:	580	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	130/570 - (22%)
Similarity:	221/570 - (38%)	Gaps:	125/570 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLFVAVAVGDSLDVCLEDMGCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEG 72
            :||...:...||| :.....|.:.|.     :.|::..|..||||:||||.||.:.|.....|:|
Worm     7 LLLIFIINAADSL-IIHTSFGHLEGA-----EIGDYHLFKKIPFAKPPVGNLRFQKPEAAGKWDG 65

  Fly    73 VLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDK-LPVMVYIHGGGFFSGSAHPM 136
            :..|.....:|:..|...|.......||||::|::..|...:.: ..:.|||||||....||  :
Worm    66 IRSAIEYGPACMSNSSKTKSPQKWVDEDCLHVNIFTSKKCLKSRNCAIAVYIHGGGLTYDSA--V 128

  Fly   137 ASGPEYLMDT---NKVVMVTMNYRLGPFGFLSTGDEHM-PGNFGFKDQRLALQWIQKHIATFGGD 197
            ......|:||   ..|::|...:|||.|...:..:::: |.|....|..|||::::..|.:|||:
Worm   129 MFNDTVLLDTFVKRDVILVIPGFRLGIFSHFTVHNQNVAPNNLALYDITLALEFVKSEIHSFGGN 193

  Fly   198 PKKVTVLGHSAGGISAHLHMISP---NSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRL----- 254
            .:|:|:.|||.||..|.:...|.   ....|||.::.::|..:...   |||.:...:|.
Worm   194 SQKITLFGHSYGGGLASMMTFSSEINRDLSLFQQAIVMSGGFYFEE---LKDHIEGTKRFVEYAN 255

  Fly   255 -GKELAIDQAESLSSQDLAEALRNVCPKKL----LVSVDSLKVWDNMPHLTTLPVLEAPSPDA-- 312
             ...|.:::....|.|   |.....|.:||    |:.:..|......|....:.:.|...||.
Worm   256 CSVPLKLERKMERSQQ---EMYMMKCLQKLSGMELLRIQRLLEDKGYPDFGGVILREPLFPDVKK 317

  Fly   313 -FLVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPE 376
             .|::.|         ..:|.:...::          ..|.:..::..|.: :||     ...|:
Worm   318 FELLKSP---------KNIPMLTGCTN----------LEFDHESIKVPFGK-YLE-----FENPD 357

  Fly   377 GTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIF 441
            ....:..:::....:.:|:..:....:.|           |:...|:      ||.||.:..|::
Worm   358 ECDEKYRNDVESGVENRGNHTDKTQGIIL-----------PLKLQIN------NLLENNVTAYLY 405

  Fly   442 EFAGLNSITKFFAGTTDDYGLGAVHMDD-----GLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMT 501
            |:.               |.....|.||     |:|.         |.||..:..:.|....::.
Worm   406 EYT---------------YPKHGRHTDDLSYIMGVHA---------FEKDENEVHLEQVYKDMVI 446

  Fly   502 DFAK---TGVFHEESICKVSDFKEQGMCNYLHFGGNK--------EKYLE 540
            :|.|   .|:..|:|        ||....|.....|:        .||.|
Worm   447 NFIKLGEPGMGFEKS--------EQNESTYFDIYWNETTGERPRMRKYFE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	114/505 (23%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	34/108 (31%)
cest-5.1	NP_501022.3	Abhydrolase	19..495	CDD:389770	126/558 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740