DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jhedup and Ces1e

DIOPT Version :9

Sequence 1:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_598421.1	Gene:	Ces1e / 13897	MGIID:	95432	Length:	562	Species:	Mus musculus

Alignment Length:	574	Identity:	166/574 - (28%)
Similarity:	269/574 - (46%)	Gaps:	96/574 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 MRGTLMPGYQSGE-----FEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYF 89
            ::|.::..|.|.|     ...|:|:|||:||:|.||...|.|.|||..|.:|.:....|.|....
Mouse    30 VQGKVLGKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCFQDPVT 94

  Fly    90 A-----------KEWGLMGVEDCLYLNVYRPKNRAE-DKLPVMVYIHGGGFFSGSAHPMASGPEY 142
            .           ::..|...|||||||:|.|.:..: |:|||||:|||||...|.|   ::....
Mouse    95 GQIVNDLLTNRKEKIPLQFSEDCLYLNIYTPADLTKSDRLPVMVWIHGGGLVLGGA---STYDGL 156

  Fly   143 LMDTNK-VVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGH 206
            ::.|:: ||:|.:.||||.:||.||||||..||:|..||..||.|:|.:||.|||||..||:.|.
Mouse   157 VLSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTIFGE 221

  Fly   207 SAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELA-IDQAESLSSQD 270
            ||||.|..:.::||.:|.|||.::|.:| :.|:|..:.|:    .|.|.:::| |...::.:|..
Mouse   222 SAGGESVSVLVLSPLAKNLFQRAISESG-VALTAGLVKKN----TRPLAEKIAVISGCKNTTSAA 281

  Fly   271 LAEALRNVCPKKLLVSVDSLKVW---------DNMPHLTTL--PVLEAPSPDAFLVEDPLDAHRA 324
            :...||....::||.:...|.::         .:.|.:.|:  .||....|:..|.|.
Mouse   282 MVHCLRQKTEEELLGTTLKLNLFKLDLHGDSRQSHPFVPTVLDGVLLPKMPEEILAEK------- 339

  Fly   325 GRINQMPWILSLSSRA-GEGSLFIMRAFIN-PKLRAEFNE----NFLEHMALLLNLPEGTPVQMV 383
             ..|.:|:|:.::.:. |    :|:...:| |....:.::    :.|:..:.||||||......:
Mouse   340 -NFNTVPYIVGINKQEFG----WILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPEDAIAVAI 399

  Fly   384 SEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEEN-PLFIYIFEFAGLN 447
            .:.|...|:.|  .|.|.:|   |:.||..|..|     |..|:..:.:.. |.::|.|:::
Mouse   400 EKYLRDKDYTG--RNKDQLL---ELIGDVVFGVP-----SVIVSRGHRDAGAPTYMYEFQYS--- 451

  Fly   448 SITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEE 512
              ..|.:....|..:|. |.|:.......|:....  ...|:..:.:.|.....:||:.|..:.:
Mouse   452 --PSFSSEMKPDTVVGD-HGDEIYSVFGAPILRGG--TSEEEINLSKMMMKFWANFARNGNPNGQ 511

  Fly   513 SICKVSDFKEQGMCNYLHFGGN-------KEKYLEDIRNSITLTAFPIWKKLFA 559
            .:....::.::.  .||..|..       |||.:          ||  |.:|.|
Mouse   512 GLPHWPEYDQKE--GYLQIGATTQQAQKLKEKEV----------AF--WTELLA 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	154/513 (30%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	52/105 (50%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	163/567 (29%)
		Aes	44..>242	CDD:223730	86/200 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850